10377-95-4

Basic information

• Product Name: 2-[bis(2-hydroxyethyl)amino]ethyl salicylate
• Synonyms: 2-[bis(2-hydroxyethyl)amino]ethyl salicylate;2-Hydroxybenzoic acid 2-[bis(2-hydroxyethyl)amino]ethyl ester
• CAS NO: 10377-95-4
• Molecular Formula: C₁₃H₁₉NO₅
• Molecular Weight: 269.29366
• EINECS: 233-830-9
• Mol File: 10377-95-4.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 458.5 °Cat760mmHg
• Flash Point: 231.1 °C
• Appearance: /
• Density: 1.278 g/cm³
• Vapor Pressure: 3.36E-09mmHg at 25°C
• Refractive Index: 1.577
• CAS DataBase Reference: 2-[bis(2-hydroxyethyl)amino]ethyl salicylate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[bis(2-hydroxyethyl)amino]ethyl salicylate(10377-95-4)
• EPA Substance Registry System: 2-[bis(2-hydroxyethyl)amino]ethyl salicylate(10377-95-4)

Safety Data

• Hazardous Substances Data: 10377-95-4(Hazardous Substances Data)

Usage

General Description

2-[bis(2-hydroxyethyl)amino]ethyl salicylate is an organic compound that belongs to the category of salicylates, which are derivatives of salicylic acid. It is used as an active ingredient in various topical analgesic and anti-inflammatory products, such as creams, ointments, and gels, due to its pain-relieving and anti-inflammatory properties. This chemical compound works by inhibiting the production of prostaglandins, which are responsible for causing pain and inflammation in the body. It is commonly used for the relief of minor aches and pains associated with conditions such as arthritis, muscle strains, and backaches. Additionally, it is frequently included in sunscreens and other skincare products for its UV-protective properties.

InChI:InChI=1/C13H19NO5/c15-8-5-14(6-9-16)7-10-19-13(18)11-3-1-2-4-12(11)17/h1-4,15-17H,5-10H2

Upstream product

• 102-71-6 triethanolamine 
• 118-55-8 phenyl Salicylate 

Relevant articles and documents

Intramolecular General Base Catalysis and the Rate-determining Step in the Nucleophilic Cleavage of Ionized Phenyl Salicylate with Primary and Secondary Amines

The nucleophilic second-order rate constants for the reactions of ionized phenyl salicylate (PS-) with primary and secondary amines have revealed Broensted plots of slopes βnuc1 = 0.52+/-0.06 and βnuc2 = 0.27+/-0.05, respectively.The suggested stepwise reaction mechanism involves the intramolecular proton transfer from cationic nitrogen to the anionic phenolic oxygen to form the monoanionic tetrahedral addition intermediate as the rate-determining step.The low value of βnuc2 is attributed to the extensive of proton transfer in the late transition state while the large value of βnuc1 is ascribed to the proton transfer in the early transition state of the rate-determining step.However, these low and high values of βnuc2 and βnuc1, respectively, are also compatible with the occurence of respective early and late transition states in the rate-determining step involving concerted intramolecular general base-catalysed nucleophilic attack at the carbonyl carbon of PS-.Significantly large positive deviations from Broensted plots have been observed for the reactivities of α-nucleophiles toward PS-.Monoprotonated ethane-1,2-diamine is ca. 20-fold more reactive than would be expected from its basicity, and this is attributed to the occurence of the intramolecular general acid catalysis.The reactions of PS- with hydroxylamine and N-methylhydroxylamine involve ca. >/=70 percent aminolysis and -.