103775-14-0

Basic information

• Product Name: MOEXIPRILAT HYDRATE
• Synonyms: Moexiprilat;2-[2-(1-Carboxy-3-phenyl-propylamino)-propionyl]-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic Acid Hydrate;(3S)-2-[(2S)-2-[[(1S)-1-Carboxy-3-phenylpropyl]aMino]-1-oxopropyl]-1,2,3,4-tetrahydro-6,7-diMethoxy-3-isoquinolinecarboxylic Acid;[3S-[2[R*(R*)],3R*]]-2-[2-[(1- Carboxy-3-phenylpropyl)aMino]-1-oxopropyl]-1,2,3,4-tetrahydro-6,7-diMethoxy-3-isoquinolinecarboxylic Acid;RS 10029;(3S)-2-[(2S)-2-[[(1S)-1-Carboxy-3-(phenyl-d5)propyl]aMino]-1-oxopropyl]-1,2,3,4-tetrahydro-6,7-diMethoxy-3-isoquinolinecarboxylic Acid;[3S-[2[R*(R*)],3R*]]-2-[2-[(1- Carboxy-3-(phenyl-d5)propyl)aMino]-1-oxopropyl]-1,2,3,4-tetrahydro-6,7-diMethoxy-3-isoquinolinecarboxylic Acid;Moexipril Related CoMpound A
• CAS NO: 103775-14-0
• Molecular Formula: C₂₅H₃₀N₂O₇
• Molecular Weight: 470.51
• Product Categories: All Inhibitors;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Aromatics;Chiral Reagents
• Mol File: 103775-14-0.mol
• Article Data: 2

Chemical Properties

• Melting Point: 145-1700C
• Boiling Point: 717.4°Cat760mmHg
• Flash Point: 387.7°C
• Appearance: /
• Density: 1.284g/cm³
• Vapor Pressure: 1.34E-21mmHg at 25°C
• Refractive Index: 1.588
• Storage Temp.: Hygroscopic, -20°C Freezer, Under Inert Atmosphere
• CAS DataBase Reference: MOEXIPRILAT HYDRATE(CAS DataBase Reference)
• NIST Chemistry Reference: MOEXIPRILAT HYDRATE(103775-14-0)
• EPA Substance Registry System: MOEXIPRILAT HYDRATE(103775-14-0)

Safety Data

• Hazardous Substances Data: 103775-14-0(Hazardous Substances Data)

Usage

Chemical Properties

White Crystalline Solid

Uses

Different sources of media describe the Uses of 103775-14-0 differently. You can refer to the following data:
1. Analogue of Quinapril
2. Angiotensin converting enzyme (ACE) inhibitor; dimethoxy analog of Quinapril. Antihypertensive.
3. Moexiprilat is an angiotensin converting enzyme (ACE) inhibitor; dimethoxy analog of Quinapril. Antihypertensive.

InChI:InChI=1/C25H30N2O7/c1-15(26-19(24(29)30)10-9-16-7-5-4-6-8-16)23(28)27-14-18-13-22(34-3)21(33-2)12-17(18)11-20(27)25(31)32/h4-8,12-13,15,19-20,26H,9-11,14H2,1-3H3,(H,29,30)(H,31,32)/t15-,19-,20-/m0/s1

Upstream product

• 82586-51-4 <3S-<2>,3R*>-2-<2-<<1-(ethoxycarbonyl)-3-phenylpropyl>amino>-1-oxopropyl>-1,2,3,4-tetrahydro-6,7-dimethoxy-3-isoquinolinecarboxylic acid, phenylmethyl ester, hydrochloride 
• 82586-52-5 moexipril hydrochloride 

Relevant articles and documents

The influence of relative humidity and temperature on stability of moexipril hydrochloride in solid phase

Kinetic and thermodynamic parameters of the decomposition of moexipril hydrochloride in solid phase in the absence and presence of humidity were calculated. The evaluation of stability of moexipril hydrochloride was followed by the HPLC method. The applied method was validated (evaluation of the following parameters: selectivity, linearity, precision, limit of detection (LOD), limit of quantification (LOQ) and repeatability). The effect of humidity on the stability of MHCl in solid phase at 363 K was described by the equation: In ki = ax + b = (0.0676 ± 0.016) · RH% - (15.53 ± 0.78). Identification of degradation products of MHCl were carried out by the HPLC-MS method.