103782-06-5

Basic information

• Product Name: (7R)-10α-[(3-Amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-8-ethyl-7,8,9,10-tetrahydro-1,6,7β,8α,11-pentahydroxy-5,12-naphthacenedione
• Synonyms: (7R)-10α-[(3-Amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-8-ethyl-7,8,9,10-tetrahydro-1,6,7β,8α,11-pentahydroxy-5,12-naphthacenedione
• CAS NO: 103782-06-5
• Molecular Weight: 0
• Mol File: 103782-06-5.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (7R)-10α-[(3-Amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-8-ethyl-7,8,9,10-tetrahydro-1,6,7β,8α,11-pentahydroxy-5,12-naphthacenedione(CAS DataBase Reference)
• NIST Chemistry Reference: (7R)-10α-[(3-Amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-8-ethyl-7,8,9,10-tetrahydro-1,6,7β,8α,11-pentahydroxy-5,12-naphthacenedione(103782-06-5)
• EPA Substance Registry System: (7R)-10α-[(3-Amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-8-ethyl-7,8,9,10-tetrahydro-1,6,7β,8α,11-pentahydroxy-5,12-naphthacenedione(103782-06-5)

Safety Data

• Hazardous Substances Data: 103782-06-5(Hazardous Substances Data)

Upstream product

• 76034-18-9 13-deoxocarminomycin 
• 141085-71-4 10-O-acetyl-3'-N-trifluoroacetyloxaunomycin 
• 132446-61-8 10-O-acetyl-4'-O-p-nitrobenzoyl-3'-N-trifluoroacetyloxaunomycin 

Relevant articles and documents

New anthracycline antibiotics 10-epi-oxaunomycin and 10-epi-11-deoxyoxaunomycin

Two new anthracycline antibiotics, 10-epi-oxaunomycin and 10-epi-11-deoxyoxaunomycin, were photochemically obtained from anthracycline metabolites D788-1 (10-carboxy-13-deoxocarminomycin) and D788-3 (10-carboxy-11-deoxy-13-deoxocarminomycin) and were examined for their growth inhibitory activities on cultured L1210 leukemic cells. Effects of the S configuration of C-10 and a hydroxyl group at C-11 on the bioactivity are discussed in comparison with oxaunomycin and 11-deoxyoxaunomycin.

Synthesis of a potent rhodomycin, oxaunomycin, and its analogs

Oxaunomycin (3) and its regioisomer (6) were synthesized by employing regioselective glycosidations of the C-7 hydroxyl group of 10-O-acetyl-β-rhodomycinone (16) and the C-10 hydroxyl group of the C-7,9-O-phenylboronate (14), respectively, in the presence