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1037827-01-2

N-(4-amino-3,4-dioxo-1-phenylbutan-2-yl)-2-(3-(4-(trifluoromethyl)phenyl)-1H-pyrazol-1-yl)nicotinamide is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1037827-01-2 Structure

  • Basic information

    1. Product Name: N-(4-amino-3,4-dioxo-1-phenylbutan-2-yl)-2-(3-(4-(trifluoromethyl)phenyl)-1H-pyrazol-1-yl)nicotinamide
    2. Synonyms:
    3. CAS NO:1037827-01-2
    4. Molecular Formula:
    5. Molecular Weight: 507.472
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1037827-01-2.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: N-(4-amino-3,4-dioxo-1-phenylbutan-2-yl)-2-(3-(4-(trifluoromethyl)phenyl)-1H-pyrazol-1-yl)nicotinamide(CAS DataBase Reference)
    10. NIST Chemistry Reference: N-(4-amino-3,4-dioxo-1-phenylbutan-2-yl)-2-(3-(4-(trifluoromethyl)phenyl)-1H-pyrazol-1-yl)nicotinamide(1037827-01-2)
    11. EPA Substance Registry System: N-(4-amino-3,4-dioxo-1-phenylbutan-2-yl)-2-(3-(4-(trifluoromethyl)phenyl)-1H-pyrazol-1-yl)nicotinamide(1037827-01-2)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1037827-01-2(Hazardous Substances Data)

1037827-01-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1037827-01-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,3,7,8,2 and 7 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1037827-01:
(9*1)+(8*0)+(7*3)+(6*7)+(5*8)+(4*2)+(3*7)+(2*0)+(1*1)=142
142 % 10 = 2
So 1037827-01-2 is a valid CAS Registry Number.

1037827-01-2Downstream Products

1037827-01-2Relevant articles and documents

Discovery of Novel and Highly Selective Inhibitors of Calpain for the Treatment of Alzheimer's Disease: 2-(3-Phenyl-1H-pyrazol-1-yl)-nicotinamides

Kling, Andreas,Jantos, Katja,Mack, Helmut,Hornberger, Wilfried,Drescher, Karla,Nimmrich, Volker,Relo, Ana,Wicke, Karsten,Hutchins, Charles W.,Lao, Yanbin,Marsh, Kennan,Moeller, Achim

, p. 7123 - 7138 (2017/09/07)

Calpain overactivation has been implicated in a variety of pathological disorders including ischemia/reperfusion injury, cataract formation, and neurodegenerative diseases such as Alzheimer's disease (AD). Herein we describe our efforts leading to the ide

CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS

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Page/Page column 93-94, (2008/12/07)

The present invention relates to novel carboxamide compounds and their use for the manufacture of a medicament. The carboxamide compounds are inhibitors of calpain (calcium dependant cysteine proteases). The invention therefore also relates to the use of these carboxamide compounds for treating a disorder associated with an elevated calpain activity. The carboxamide compounds are compounds of the general formula (I) in which R1, R2, R3a, R3b, W, Y and X have the meanings mentioned in the claims and 15 the description, the tautomers thereof and the pharmaceutically suitable salts thereof. In particular, the compounds have the general formula I-A.a' and I-A.a'' in which m, E, R1, R3a, R3b, R2, Ry, Rw and Rw6* have the meanings mentioned in the claims, n is 0, 1 or 2, the tautomers thereof and the pharmaceutically suitable salts thereof.

Carboxamide compounds and their use as calpain inhibitors

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Page/Page column 44, (2008/12/08)

The present invention relates to novel carboxamide compounds and their use for the manufacture of a medicament. The carboxamide compounds are inhibitors of calpain (calcium dependant cysteine proteases). The invention therefore also relates to the use of

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