1037828-54-8

Basic information

• Product Name: 2-(3-phenyl-1H-pyrazol-1-yl)-3-pyridinecarboxylic acid
• Synonyms: 2-(3-phenyl-1H-pyrazol-1-yl)-3-pyridinecarboxylic acid
• CAS NO: 1037828-54-8
• Molecular Weight: 265.271
• Mol File: 1037828-54-8.mol

Chemical Properties

• CAS DataBase Reference: 2-(3-phenyl-1H-pyrazol-1-yl)-3-pyridinecarboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-phenyl-1H-pyrazol-1-yl)-3-pyridinecarboxylic acid(1037828-54-8)
• EPA Substance Registry System: 2-(3-phenyl-1H-pyrazol-1-yl)-3-pyridinecarboxylic acid(1037828-54-8)

Safety Data

• Hazardous Substances Data: 1037828-54-8(Hazardous Substances Data)

Usage

Structure

Contains both a pyrazole and pyridine ring

Properties

Has potential pharmacological properties, including anti-inflammatory and anti-cancer activities

Potential uses

As a metal chelator for biomedical applications

Importance

Unique structure makes it an important molecule for further exploration in the fields of pharmaceuticals and biotechnology.

Upstream product

• 1037828-53-7 ethyl 2-(3-phenyl-1H-pyrazol-1-yl)nicotinate 
• 2458-26-6 3-phenylpyrazole 
• 1452-94-4 ethyl 2-chloronicotinate 

Downstream Products

• 1037826-43-9 N-(4-amino-3,4-dioxo-1-phenylbutan-2-yl)-2-(3-phenyl-1H-pyrazol-1-yl)nicotinamide 
• 1037826-44-0 N-(1-amino-1,2-dioxoheptan-3-yl)-2-(3-phenyl-1H-pyrazol-1-yl)nicotinamide 
• 1037827-50-1 (S)-N-(4-amino-3,4-dioxo-1-phenylbutan-2-yl)-2-(3-phenyl-1H-pyrazol-1-yl)nicotinamide 
• 1311474-15-3 N-(4-{[2-(4-Morpholinyl)ethoxy]amino}-3,4-dioxo-1-phenyl-2-butanyl)-2-(3-phenyl-1H-pyrazol-1-yl)nicotinamide 
• 1311473-99-0 N-{4-[(Cyclopentyloxy)amino]-3,4-dioxo-1-phenyl-2-butanyl}-2-(3-phenyl-1H-pyrazol-1-yl)nicotinamide 
• 1311474-09-5 N-{4-[(Cyclobutyloxy)amino]-3,4-dioxo-1-phenyl-2-butanyl}-2-(3-phenyl-1H-pyrazol-1-yl)nicotinamide 
• 1311474-19-7 N-{4-[(Cyclopropylmethoxy)amino]-3,4-dioxo-1-phenyl-2-butanyl}-2-(3-phenyl-1H-pyrazol-1-yl)nicotinamide 
• 1311473-71-8 N-(4-(Allyloxyamino)-3,4-dioxo-1-phenylbutan-2-yl)-2-(3-phenyl-1H-pyrazol-1-yl)nicotinamide 
• 1311473-87-6 N-[4-(Isopropoxyamino)-3,4-dioxo-1-phenyl-2-butanyl]-2-(3-phenyl-1H-pyrazol-1-yl)nicotinamide 
• 1311473-89-8 N-[3,4-Dioxo-1-phenyl-4-(propoxyamino)-2-butanyl]-2-(3-phenyl-1H-pyrazol-1-yl)nicotinamide 
• 1311473-65-0 N-(4-(Ethoxyamino)-3,4-dioxo-1-phenylbutan-2-yl)-2-(3-phenyl-1H-pyrazol-1-yl)nicotinamide 
• 1311473-38-7 N-(4-(methoxyamino)-3,4-dioxo-1-phenylbutan-2-yl)-2-(3-phenyl-1H-pyrazol-1-yl)nicotinamide 

Relevant articles and documents

CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF

Small molecule calpain modulator compounds, including their pharmaceutically acceptable salts, can be included in pharmaceutical compositions. The compounds can be useful in inhibiting calpain, or competitive binding with calpastatin, by contacting them with CAPN1, CAPN2, and/or CAPN9 enzymes residing inside a subject. The compounds and composition can also be administered to a subject in order to treat a fibrotic disease or a secondary disease state or condition of a fibrotic disease.

Discovery of Novel and Highly Selective Inhibitors of Calpain for the Treatment of Alzheimer's Disease: 2-(3-Phenyl-1H-pyrazol-1-yl)-nicotinamides

Calpain overactivation has been implicated in a variety of pathological disorders including ischemia/reperfusion injury, cataract formation, and neurodegenerative diseases such as Alzheimer's disease (AD). Herein we describe our efforts leading to the ide

CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS

The present invention relates to novel carboxamide compounds and their use for the manufacture of a medicament. The carboxamide compounds are inhibitors of calpain (calcium dependant cysteine proteases). The invention therefore also relates to the use of these carboxamide compounds for treating a disorder associated with an elevated calpain activity. The carboxamide compounds are compounds of the general formula (I) in which R1, R2, R3a, R3b, W, Y and X have the meanings mentioned in the claims and 15 the description, the tautomers thereof and the pharmaceutically suitable salts thereof. In particular, the compounds have the general formula I-A.a' and I-A.a'' in which m, E, R1, R3a, R3b, R2, Ry, Rw and Rw6* have the meanings mentioned in the claims, n is 0, 1 or 2, the tautomers thereof and the pharmaceutically suitable salts thereof.

Carboxamide compounds and their use as calpain inhibitors

The present invention relates to novel carboxamide compounds and their use for the manufacture of a medicament. The carboxamide compounds are inhibitors of calpain (calcium dependant cysteine proteases). The invention therefore also relates to the use of