103786-13-6

Basic information

• Product Name: erythro-3-diphenylphosphinoyl-5-phenylpentan-2-ol
• CAS NO: 103786-13-6
• Molecular Weight: 364.424
• Mol File: 103786-13-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: erythro-3-diphenylphosphinoyl-5-phenylpentan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: erythro-3-diphenylphosphinoyl-5-phenylpentan-2-ol(103786-13-6)
• EPA Substance Registry System: erythro-3-diphenylphosphinoyl-5-phenylpentan-2-ol(103786-13-6)

Safety Data

• Hazardous Substances Data: 103786-13-6(Hazardous Substances Data)

Upstream product

• 23896-91-5 (3-phenylpropyl)diphenylphosphine oxide 
• 75-07-0 acetaldehyde 

Downstream Products

• 1745-16-0 (E)-3-pentenylbenzene 
• 16487-65-3 (Z)-1-phenyl-3-pentene 

Relevant articles and documents

The Stereocontrolled Horner-Wittig Reaction: Synthesis of Disubstituted Alkenes

Addition of the lithium derivatives of phosphine oxides Ph2P(O)CH2R1 to aldehydes gives erythro adducts (11) with good stereoselectivity.Reduction of α-diphenylphosphinoyl ketones (12) gives threo adducts (11) with even better stereoselectivity.Purification by flash chromatography and/or crystallisation followed by elimination of Ph2PO2 gives pure Z- or E-alkenes with high material conversion.Explanations are offered for the stereoselectivities, conditions defined for full stereochemical control, and guidelines suggested for approaches to a given alkene.