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Usage

Uses

Used in Medicinal Chemistry and Drug Development:
1-Methylindolin-6-amine is used as a key intermediate in the synthesis of pharmaceuticals for its structural properties and potential biological activities, contributing to the development of new drugs with therapeutic benefits.
Used in Agrochemicals Synthesis:
In the agrochemical industry, 1-Methylindolin-6-amine is utilized as an intermediate in the production of various agrochemicals, aiding in the development of effective compounds for agricultural applications.
Used as an Enzyme Inhibitor:
1-Methylindolin-6-amine has been studied for its potential role as an inhibitor of specific enzymes, which can be crucial in the treatment of certain diseases by targeting and modulating enzyme activity.
Used in the Synthesis of Heterocyclic Compounds:
1-METHYLINDOLIN-6-AMINE is employed as a building block in the synthesis of diverse heterocyclic compounds, which are important in pharmaceutical chemistry for their wide range of biological activities and potential therapeutic applications.

Upstream product

• 115210-53-2 1-methyl-6-nitroindoline 
• 19727-83-4 6-nitroindoline 

Relevant academic research and scientific papers

QUINAZOLINE DERIVATIVES FOR USE AGAINST CANCER

The invention concerns quinazoline derivatives of Formula (I) or a pharmaceutically-acceptable salt, solvate or pro-drug thereof, wherein each of p, R1, q, R2, R3, R4, R5, Ring A, X1, R6, r and R7 has any of the meanings defined in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use in the treatment of cell proliferative disorders or in the treatment of disease states associated with angiogenesis and/or vascular permeability.

Non-peptidic NPY Y2 receptor inhibitors

The invention provides novel non-peptidic NPY Y2 receptor inhibitors useful in treating or preventing: anxiolytic disorders or depression; injured mammalian nerve tissue; conditions responsive to treatment through administration of a neurotrophic factor; neurological disorders; bone loss; substance related disorders; obesity; or an obesity-related disorder. Compounds of the invention are also useful in modulating endocrine functions, particularly endocrine functions controlled by the pituitary and hypothalamic glands, and are therefore useful in the treatment or prevention of inovulation and infertility.

Vanilloid receptor ligands and their use in treatments

Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritis, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.