103806-58-2

Upstream product

• 1123-49-5 3,5-dimethyl-4-nitroisoxazole 
• 100-83-4 meta-hydroxybenzaldehyde 

Downstream Products

• 98239-51-1 3-[1-(3,5-Dimethyl-1-phenyl-1H-pyrazol-4-yl)-2-(3-methyl-4-nitro-isoxazol-5-yl)-ethyl]-phenol 
• 98239-40-8 3-[1-(3,5-Dimethyl-1H-pyrazol-4-yl)-2-(3-methyl-4-nitro-isoxazol-5-yl)-ethyl]-phenol 
• 98239-55-5 3-[1-(3-Hydroxy-phenyl)-2-(3-methyl-4-nitro-isoxazol-5-yl)-ethyl]-pentane-2,4-dione 
• 103806-33-3 2-Acetyl-3-(3-hydroxy-phenyl)-4-(3-methyl-4-nitro-isoxazol-5-yl)-butyric acid ethyl ester 

Relevant academic research and scientific papers

Tandem grinding reactions involving aldol condensation and Michael addition in sequence for synthesis of 3,4,5-trisubstituted isoxazoles

A one-pot, base-catalyzed, tandem grinding process involving carrying out aldol condensation and Michael addition in sequence to produce 3,4,5-trisubstituted isoxazoles from 3,5-dimethyl-4-nitroisoxazole, aromatic aldehydes and activated methylene compoun

Chemistry of Heterocylces: Part VIII - Synthesis of Isoxazolylethylpyrazoles

The base-catalysed addition of acetylacetone to 3-methyl-4-nitro-5-styrylisoxazoles (II) leads to the Michael adducts 3-pentane-2,4-diones (III).These β-diketones (III) undergo cyclization with hydrazine sulphate and phenylhydrazine to furnish pyrazoles (IV) and N-phenylpyrazoles (V), respectively.