10381-67-6

Upstream product

• 21066-59-1 (S)-p-tolyl p-trifluoromethylphenyl sulfoxide 
• 911820-09-2 3-[(4-methylphenyl)sulfinyl]propanoic acid tert-butyl ester 
• 455-13-0 4-Iodobenzotrifluoride 
• 10381-71-2 p-tolyl allyl sulfoxide 

Downstream Products

• 10355-12-1 1-(4-methoxyphenyl)-4-(trifluoromethyl)benzene 
• 53040-92-9 4-(4-tolyl)anisole 

Relevant academic research and scientific papers

Aryl sulfoxides from aliyi sulfoxides via [2,3]-sigmatropic rearrangement and domino Pd-catalyzed generation/ arylation of sulfenate anions

(Figure presented) Allylic sulfoxides, via [2,3]-sigmatropic rearrangement and oxidative addition of the resulting allylic sulfonate esters to Pd(0), are found to be excellent precursors of sulfenate anions. This hitherto unknown reactivity is applied in a new Pd(0)-catalyzed domino sequence involving sulfonate anion generation followed by arylation to afford aryl sulfoxides.

Aryl sulfoxides via palladium-catalyzed arylation of sulfenate anions

(Chemical Equation Presented) Palladium-catalyzed arylation of sulfenate anions generated from β-sulfinyl esters can take place under biphasic conditions. This hitherto unknown reaction provides a simple, mild, and efficient route to aryl sulfoxides in good yields. The development of a new pseudo-domino type I procedure involving a sulfinylation followed by a Mirozoki-Heck coupling is also described.