103816-16-6

Basic information

• Product Name: 11-Desethyl Irinotecan
• Synonyms: 11-Desethyl Irinotecan;Irinotecan Impurity A;10-[4-(1-Piperidino)-1-piperidinocarbonyloxy]camptothecin
• CAS NO: 103816-16-6
• Molecular Formula: C₃₁H₃₄N₄O₆
• Molecular Weight: 558.62486
• Product Categories: Aromatics, Heterocycles, Impurities, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 103816-16-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 865.3±65.0 °C(Predicted)
• Appearance: /
• Density: 1.45±0.1 g/cm3(Predicted)
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
• PKA: 11.20±0.20(Predicted)
• CAS DataBase Reference: 11-Desethyl Irinotecan(CAS DataBase Reference)
• NIST Chemistry Reference: 11-Desethyl Irinotecan(103816-16-6)
• EPA Substance Registry System: 11-Desethyl Irinotecan(103816-16-6)

Safety Data

• Hazardous Substances Data: 103816-16-6(Hazardous Substances Data)

Usage

Uses

11-Desethyl Irinotecan is an impurity of the DNA topoisomerase inhibitor Irinotecan (I767500).

Upstream product

• 143254-82-4 4-piperidinopiperidine-1-carbonyl chloride hydrochloride 
• 19685-09-7 (S)-10-hydroxycamptothecin 
• 4897-50-1 4-piperidinopiperidin 
• 103816-19-9 4-piperidinopiperidine-1-carbonyl chloride 
• 656233-42-0 4-nitrophenyl camptothecin-10-yl carbonate 

Downstream Products

• 1146621-77-3 10-[4-(1-piperidino)-1-piperidino]carbonyloxy-20-(4-bromophenoxy)acetylcamptothecin 
• 97682-44-5 irinotecan 

Relevant articles and documents

PODOPHYLLOTOXIN DERIVATIVES AND THEIR USE

Provided herein are compounds, compositions, and methods for treating cancer in a subject in need thereof.

Synthesis and evaluation of a DHA and 10-hydroxycamptothecin conjugate

We have synthesized a conjugate of cis-4,7,10,13,16,19-docosahexenoic acid (DHA) and 10-hydroxycamptothecin (HCPT), DHA-HCPT. The antitumor activity of DHA-HCPT was evaluated in vitro against L1210 leukemia cells and in experimental animal tumor models in