1038352-75-8Relevant academic research and scientific papers
Synthesis and cytotoxicity studies of novel 2-hydrazonylpyrido[2,3-b] pyrazin-3(4H)-ones
Zhang, Guogang,Liu, Yajing,Wang, Shuobing,Zhou, Chuan,Huang, Qingchang,Gong, Ping
, p. 49 - 56 (2012/03/11)
In an attempt to develop potent antitumor agents, a series of novel 2-hydrazonylpyrido[2,3-b]pyrazin-3(4H)-one derivatives were designed and synthesized. All the prepared compounds were screened for their cytotoxic activities against A549, MDA-MB-231 and HT-29 cell lines in vitro. Pharmacological data indicated that five of the target compounds showed cytotoxicity against A549 cell line below a concentration of 1 μM. Compound 15g was the most potent one with IC50 values of 0.19, 2.11 and 2.15 μM against A549, MDA-MB-231 and HT29 cell lines, respectively. A series of 2-hydrazonylpyrido[2,3-b]pyrazin-3(4H)-one derivatives was designed and synthesized. Preliminary structure-activity relationships suggested that compounds with 4-methoxyphenyl or 4-(trifluoromethoxy)phenyl groups on the N-4 position were generally more potent than those with an unsubstituted phenyl group. Copyright
Synthesis and in vitro cytotoxic evaluation of 2-hydrazinylpyrido[2,3-b] pyrazin-3(4H)-one derivatives
Zhang, Guo Gang,Liu, Ya Jing,Ma, Xiao Guang,Dong, Hao,Li, Ju,Gong, Ping
, p. 1223 - 1225 (2012/01/12)
A series of novel 2-hydrazinylpyrido[2,3-b]pyrazin-3(4H)-one derivatives were synthesized and evaluated for their cytotoxic activities against A549, MDA-MB-231 and HT-29 cell lines in vitro. Pharmacological data indicated that compounds 5b, 5c, 10a and 10
