103862-91-5Relevant academic research and scientific papers
Development of a Chemoenzymatic Route to (R)-Allyl-(3-amino-2-(2-methylbenzyl)propyl)carbamate
Lindhagen, Marika,Klingstedt, Tomas,Andersen, S?ren M.,Mulholland, Keith R.,Tinkler, Laura,McPheators, Gary,Chubb, Richard
, p. 65 - 69 (2016)
A chemoenzymatic route to (R)-allyl-(3-amino-2-(2-methylbenzyl)propyl)carbamate (1-(R)) has been developed on a kilogram scale. The key intermediate, 2-(2-methylbenzyl)propane-1,3-diamine 4, was isolated as a tartrate salt in a three-step sequence startin
Preparation of O-Protected Cyanohydrins by Aerobic Oxidation of α-Substituted Malononitriles in the Presence of Diarylphosphine Oxides
Zhang, Dapeng,Lian, Mingming,Liu, Jia,Tang, Shukun,Liu, Guangzhi,Ma, Cunfei,Meng, Qingwei,Peng, Haisheng,Zhu, Daling
, p. 2597 - 2601 (2019/04/17)
A mild, reagent-cyanide-free, and efficient synthesis of O-phosphinoyl-protected cyanohydrins from readily available α-substituted malononitriles was realized using diarylphosphine oxides in the presence of O2. Mechanistic studies indicated that in addition to the initial aerobic oxidation of the malononitrile derivative notable features of this process include the formation of a tetrahedral intermediate and a subsequent intramolecular rearrangement. The phosphinoyl-protecting group can be removed by alcoholysis or by reduction with DIBAL-H.
Novel Pyrimidine- And Triazine-Hepcidine Antagonists
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, (2015/09/30)
The present invention relates to new hepcidin antagonists, pharmaceutical compositions containing them and the use thereof as a drug, in particular for the treatment of iron metabolism disorders such as, in particular, iron deficiency diseases and anaemia, in particular anaemia associated with chronic inflammatory disease (ACD: anaemia of chronic disease and AI: anaemia of inflammation).
