1038622-93-3Relevant academic research and scientific papers
Novel DNA-directed alkylating agents: Design, synthesis and potent antitumor effect of phenyl N-mustard-9-anilinoacridine conjugates via a carbamate or carbonate linker
Kapuriya, Naval,Kapuriya, Kalpana,Dong, Huajin,Zhang, Xiuguo,Chou, Ting-Chao,Chen, Yu-Ting,Lee, Te-Chang,Lee, Wen-Chuan,Tsai, Tung-Hu,Naliapara, Yogesh,Su, Tsann-Long
experimental part, p. 1264 - 1275 (2009/07/18)
A series of phenyl N-mustard-9-anilinoacridine conjugates via a carbamate or carbonate linker was synthesized for antitumor evaluation. The carbamate or carbonate linker is able to lower the reactivity of the phenyl N-mustard pharmacophore and thus, these
ANILINE OR PHENOL MUSTARDS LINKED TO DNA-AFFINIC MOLECULES OR WATER-SOLUBLE AROMATIC RINGS AND THEIR USE AS CANCER THERAPEUTIC AGENTS
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Page/Page column 18, (2008/12/06)
New aniline or phenol N-mustards linked to DNA-affinity carriers (such as 9-anilinoacridines, acridines andquinolines), aminobenzamides or aminophenol ethers by a urea, carbamic acid, carbanic acid ester, hydxazine urea, hydrazine carbamic acid ester, phenoxyurea, phenoxycarbamic acid ester linkage with improved chemical stability and anti-tumor therapeutic efficacy are provided.
