1038622-94-4Relevant articles and documents
Novel DNA-directed alkylating agents: Design, synthesis and potent antitumor effect of phenyl N-mustard-9-anilinoacridine conjugates via a carbamate or carbonate linker
Kapuriya, Naval,Kapuriya, Kalpana,Dong, Huajin,Zhang, Xiuguo,Chou, Ting-Chao,Chen, Yu-Ting,Lee, Te-Chang,Lee, Wen-Chuan,Tsai, Tung-Hu,Naliapara, Yogesh,Su, Tsann-Long
experimental part, p. 1264 - 1275 (2009/07/18)
A series of phenyl N-mustard-9-anilinoacridine conjugates via a carbamate or carbonate linker was synthesized for antitumor evaluation. The carbamate or carbonate linker is able to lower the reactivity of the phenyl N-mustard pharmacophore and thus, these