103865-02-7Relevant articles and documents
Acyclic, orally bioavailable ketone-based cathepsin K inhibitors
Barrett, David G.,Catalano, John G.,Deaton, David N.,Long, Stacey T.,McFadyen, Robert B.,Miller, Aaron B.,Miller, Larry R.,Samano, Vicente,Tavares, Francis X.,Wells-Knecht, Kevin J.,Wright, Lois L.,Zhou, Hui-Qiang Q.
, p. 22 - 27 (2007/10/03)
Starting from a potent ketone-based inhibitor with poor drug properties, incorporation of P2-P3 elements from a ketoamide-based inhibitor led to the identification of a hybrid series of ketone-based cathepsin K inhibitors with better
