103868-29-7

Basic information

• Product Name: 3-Pyridinecarbonitrile, 5-acetyl-4-(4-chlorophenyl)-1,2-dihydro-6-methyl-2-thioxo-
• CAS NO: 103868-29-7
• Molecular Formula: C15H11ClN2OS
• Molecular Weight: 302.784
• Mol File: 103868-29-7.mol

Chemical Properties

• CAS DataBase Reference: 3-Pyridinecarbonitrile, 5-acetyl-4-(4-chlorophenyl)-1,2-dihydro-6-methyl-2-thioxo-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Pyridinecarbonitrile, 5-acetyl-4-(4-chlorophenyl)-1,2-dihydro-6-methyl-2-thioxo-(103868-29-7)
• EPA Substance Registry System: 3-Pyridinecarbonitrile, 5-acetyl-4-(4-chlorophenyl)-1,2-dihydro-6-methyl-2-thioxo-(103868-29-7)

Safety Data

• Hazardous Substances Data: 103868-29-7(Hazardous Substances Data)

Upstream product

• 106763-18-2 (Z)-3-(4-Chloro-phenyl)-2-cyano-thioacrylamide 
• 123-54-6 acetylacetone 
• 39145-33-0 2-cyano-3-(4-chlorophenyl)-prop-2-enethioamide 

Downstream Products

• 233276-65-8 1-[2-acetyl-3-amino-4-(4-chloro-phenyl)-6-methyl-thieno[2,3-b]pyridin-5-yl]-ethanone 
• 233276-67-0 5-acetyl-2-(1-acetyl-2-oxo-propylsulfanyl)-4-(4-chloro-phenyl)-6-methyl-nicotinonitrile 
• 233276-73-8 5-acetyl-3-amino-4-(4-chloro-phenyl)-6-methyl-thieno[2,3-b]pyridine-2-carboxylic acid ethyl ester 
• 233276-71-6 2-[5-acetyl-4-(4-chloro-phenyl)-3-cyano-6-methyl-pyridin-2-ylsulfanyl]-3-oxo-butyric acid ethyl ester 
• 620625-59-4 2-[5-acetyl-4-(4-chloro-phenyl)-3-cyano-6-methyl-pyridin-2-ylsulfanyl]-N-phenyl-acetamide 
• 380638-18-6 5-acetyl-3-amino-4-(4-chloro-phenyl)-6-methyl-thieno[2,3-b]pyridine-2-carboxylic acid phenylamide 
• 620625-60-7 2-[5-acetyl-4-(4-chloro-phenyl)-3-cyano-6-methyl-pyridin-2-ylsulfanyl]-N-p-tolyl-acetamide 
• 620625-61-8 2-[5-acetyl-4-(4-chloro-phenyl)-3-cyano-6-methyl-pyridin-2-ylsulfanyl]-N-(4-chloro-phenyl)-acetamide 
• 647829-30-9 [5-acetyl-4-(4-chloro-phenyl)-3-cyano-6-methyl-pyridin-2-ylsulfanyl]-acetic acid ethyl ester 
• 138566-05-9 5-Acetyl-4-(4-chloro-phenyl)-6-((E)-2-thiophen-2-yl-vinyl)-2-thioxo-1,2-dihydro-pyridine-3-carbonitrile 
• 488759-89-3 Acetic acid (2S,3R,4S,5S,6R)-4,5-diacetoxy-6-acetoxymethyl-2-[5-acetyl-4-(4-chloro-phenyl)-3-cyano-6-methyl-pyridin-2-ylsulfanyl]-tetrahydro-pyran-3-yl ester 
• 488759-83-7 Acetic acid (2S,3R,4S,5R,6R)-4,5-diacetoxy-6-acetoxymethyl-2-[5-acetyl-4-(4-chloro-phenyl)-3-cyano-6-methyl-pyridin-2-ylsulfanyl]-tetrahydro-pyran-3-yl ester 
• 470456-21-4 1-[9-(4-Chloro-phenyl)-4-(3,5-dimethyl-pyrazol-1-yl)-2,7-dimethyl-pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-8-yl]-ethanone 

Relevant articles and documents

Cyanothioacetamide and its derivatives in heterocyclic synthesis: A new route for the synthesis of several pyridine and thieno[2,3-b]pyridine derivatives and their biological evaluation

Several new pyridine and thieno[2,3-b]pyridine derivatives were synthesized via the reactions of some pyridinethiones, obtained by the action of acetylacetone on some thiocarboxamidocinnamonitriles, with halogenated esters and ketones. Structures were established based on elemental and spectral data. All the synthesized compounds were tested for their biological activity.

REACTIONS OF SIX-MEMBERED HETEROCYCLIC β-ENAMINONITRILES WITH ELECTROPHILIC REAGENTS

The nitriles I reacted with acetylacetone and with ethyl acetoacetate to afford 2-amino-3-cyano-4H-pyran derivatives.They reacted further to yield pyranopyridine derivatives.The reaction of V with acetylacetone afforded the pyridinethione VIII.This afford