1038743-82-6Relevant articles and documents
A facile Horner-Wadsworth-Emmons route to 2-quinolones
Peters, Jens-Uwe,Capuano, Tony,Weber, Silja,Kritter, Stéphane,S?gesser, Matthias
, p. 4029 - 4032 (2008/09/20)
2-Quinolones are prepared from o-aminophenylketones by N-acylation with phosphonoalkanoylchlorides, followed by an intramolecular Horner-Wadsworth-Emmons olefination. The transformation proceeds under mild conditions, is generally applicable, gives good yields and can be performed either in two steps or as a one-pot reaction.