1038778-99-2Relevant academic research and scientific papers
Diversely Substituted Quinolines via Rhodium-Catalyzed Alkyne Hydroacylation
Neuhaus, James D.,Morrow, Sarah M.,Brunavs, Michael,Willis, Michael C.
, p. 1562 - 1565 (2016/05/02)
The Rh-catalyzed hydroacylative union of aldehydes and o-alkynyl anilines leads to 2-aminophenyl enones, and onward to substituted quinolines. The mild reaction conditions employed in this chemistry result in a process that displays broad functional group
A novel entry to cyclopenta[b]quinolines via thermal ring-expansion of (2-aminophenyl)-ethynyl-substituted squaric acid derivatives
Zehr, Peter S.,Kayali, Reem,Pe?a-Cabrera, Eduardo,Robles-Resendiz, Omar,Villanueva-Rendon, Alma D.,S?derberg, Bj?rn C.G.
, p. 5336 - 5344 (2008/09/21)
Substituted cyclopenta[b]quinolin-1-ones were prepared by thermal ring-expansion of substituted N-Boc protected 4-(2-aminophenylethynyl)-4-hydroxy-2-cyclobuten-1-ones forming the corresponding 2-aminophenylmethylidene substituted 4-cyclopentene-1,3-diones. Deprotection of the amine resulted in spontaneous condensation giving cyclopenta[b]quinolin-1-ones. Sodium borohydride reduction of these products produced cyclopenta[b]quinolin-1-ols.
