1038779-17-7Relevant academic research and scientific papers
A novel entry to cyclopenta[b]quinolines via thermal ring-expansion of (2-aminophenyl)-ethynyl-substituted squaric acid derivatives
Zehr, Peter S.,Kayali, Reem,Pe?a-Cabrera, Eduardo,Robles-Resendiz, Omar,Villanueva-Rendon, Alma D.,S?derberg, Bj?rn C.G.
, p. 5336 - 5344 (2008/09/21)
Substituted cyclopenta[b]quinolin-1-ones were prepared by thermal ring-expansion of substituted N-Boc protected 4-(2-aminophenylethynyl)-4-hydroxy-2-cyclobuten-1-ones forming the corresponding 2-aminophenylmethylidene substituted 4-cyclopentene-1,3-diones. Deprotection of the amine resulted in spontaneous condensation giving cyclopenta[b]quinolin-1-ones. Sodium borohydride reduction of these products produced cyclopenta[b]quinolin-1-ols.
