103890-81-9

Basic information

• Product Name: Lacidipine MonoMethyl Ester
• Synonyms: Lacidipine MonoMethyl Ester;(E)-4-[2-[3-(1,1-Dimethylethoxy)-3-oxo-1-propenyl]phenyl]-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid ethyl methyl ester;Lacidipine BP Impurity A;Lacidipine EP Impurity A;MQLPBBLKDRVRCO-BUHFOSPRSA-N
• CAS NO: 103890-81-9
• Molecular Formula: C25H31NO6
• Molecular Weight: 441.51674
• Mol File: 103890-81-9.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 547.6±50.0 °C(Predicted)
• Appearance: /
• Density: 1.139±0.06 g/cm3(Predicted)
• PKA: 2.93±0.70(Predicted)
• CAS DataBase Reference: Lacidipine MonoMethyl Ester(CAS DataBase Reference)
• NIST Chemistry Reference: Lacidipine MonoMethyl Ester(103890-81-9)
• EPA Substance Registry System: Lacidipine MonoMethyl Ester(103890-81-9)

Safety Data

• Hazardous Substances Data: 103890-81-9(Hazardous Substances Data)

Usage

Uses

Lacidipine Monomethyl Ester is an impurity of Lacidipine (L098000); a dihydropyridine calcium channel blocker. Antihypertensive.

Relevant articles and documents

1,4-dihydropyridines

Compounds are described of the formula STR1 wherein R1 and R4 independently represent a C1-4 alkyl group; R2 and R3 independently represent a C1-6 straight or branched alkyl chain which may be interrupted by an oxygen atom; R5 represents a straight or branched chain C1-13 alkyl group or a C5-8 cycloalkyl group which may be substituted by a C1-3 alkyl substitutent; The compounds represented by formula (I) reduce intracellular calcium ion cencentration by limiting transmembranal calcium ion influx and thus may be useful for the treatment of cardiovascular disorders such as hypertension.