1038924-71-8

Basic information

• Product Name: (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-aMino-2-Methylpentanoic acid hydrochloride
• Synonyms: (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-aMino-2-Methylpentanoic acid hydrochloride;(2R,4S)-4-Amino-4-([1,1'-biphenyl]-4-ylmethyl)-2-methylbutanoic acid hydrochloride(1:1);LCA696 impurity;LCZ701;LCZ-696 Impurity 2;Sacubitril Impurity 11 HCl
• CAS NO: 1038924-71-8
• Molecular Formula: C₁₈H₂₁NO₂*ClH
• Molecular Weight: 319.82578
• Product Categories: LCZ696
• Mol File: 1038924-71-8.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-aMino-2-Methylpentanoic acid hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-aMino-2-Methylpentanoic acid hydrochloride(1038924-71-8)
• EPA Substance Registry System: (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-aMino-2-Methylpentanoic acid hydrochloride(1038924-71-8)

Safety Data

• Hazardous Substances Data: 1038924-71-8(Hazardous Substances Data)

Usage

Uses

(2R,4S)-5-([1,1''-Biphenyl]-4-yl)-4-amino-2-methylpentanoic Acid Hydrochloride, is a building block used in various chemical synthesis, such as in the synthesis of Sacubitri (S080900), an antihypertensive drug.

Upstream product

• 1038924-70-7 (3R,5S)-5-({[1,1'-biphenyl]-4-yl}methyl)-3-methylpyrrolidin-2-one 
• 1038924-66-1 (3R,5S)-5-biphenyl-4-ylmethyl-1-(2,2-dimethylpropionyl)-3-methylpyrrolidin-2-one 
• 1012341-50-2 (2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid 
• 64-17-5 ethanol 
• 263551-29-7 (E)-4-(2-nitrovinyl)-1,1'-biphenyl 
• 3218-36-8 4-Phenylbenzaldehyde 
• 182680-37-1 4-(2-nitroethyl)-1,1'-biphenyl 
• 1012341-48-8 (2E,4R)-5-{[1,1'-biphenyl]-4-yl}-4-{[(tert-butoxy)carbonyl]amino}-2-methylpent-2-enoic acid 

Downstream Products

• 1012341-50-2 (2R,4S)-5-[(1,1‘-biphenyl)-4-yl]-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid 
• 752174-62-2 (2R,4S)-4-amino-5-biphenyl-4-yl-2-methylpentanoic acid ethyl ester 
• 149690-12-0 (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoic acid ethyl ester hydrochloride 

Relevant articles and documents

Application of Transition-Metal Catalysis, Biocatalysis, and Flow Chemistry as State-of-the-Art Technologies in the Synthesis of LCZ696

LCZ696 is a novel treatment for patients suffering from heart failure that combines the two active pharmaceutical ingredients sacubitril and valsartan in a single chemical compound. While valsartan is an established drug substance, a new manufacturing process suitable for large-scale commercial production had to be developed for sacubitril. The use of chemocatalysis, biocatalysis, and flow chemistry as state-of-the-art technologies allowed to efficiently build up the structure of sacubitril and achieve the defined performance targets.

BIPHENYL-SUBSTITUED 4-AMINO-BUTYRIC ACID DERIVATIVES AND THEIR USE IN THE SYNTHESIS OF NEP INHIBITORS

The invention relates to a novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, in particular neutral endopeptidase (NEP) inhibitors and prodrugs thereof.

NEW PROCESS

The present invention relates to a new chemical synthesis, intermediates and catalysts useful for the preparation of the neprilysin (NEP) inhibitor sacubitril. It further relates to new intermediate compounds and their use for said new chemical synthesis