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1038966-53-8

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1038966-53-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1038966-53-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,3,8,9,6 and 6 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1038966-53:
(9*1)+(8*0)+(7*3)+(6*8)+(5*9)+(4*6)+(3*6)+(2*5)+(1*3)=178
178 % 10 = 8
So 1038966-53-8 is a valid CAS Registry Number.

1038966-53-8Upstream product

1038966-53-8Downstream Products

1038966-53-8Relevant articles and documents

Discovery of Novel Cytochrome bc1 Complex Inhibitor Based on Natural Product Neopeltolide

Chen, Qiong,Chen, Tao,Gao, Meng-Qi,Wang, Yu-Xia,Yang, Guang-Fu,Zhang, Rui,Zhu, Xiao-Lei

, p. 263 - 268 (2022/05/12)

Background: Natural products (NPs) are important sources for the design of new drugs and agrochemicals. Neopeltolide, a marine NP, has been identified as a potent Qo-site inhibitor of cytochrome bc1 complex. Methods: In this study, a series of neopeltolide derivatives was designed and synthesized by the simplification of its 14-membered macrolactone ring with a diphenyl ether fragment. The enzymatic inhibition bioassays and mycelium growth inhibition experiments against a range of fungi were performed to determine their fungicidal activities. Results: The derivatives have potent activity against the porcine bc1 complex. Compound 8q showed the best activity with an IC50 value of 24.41 nM, which was 8-fold more effective than that of positive control azoxystrobin. Compound 8a exhibited a 100% inhibitory rate against Zymoseptoria tritici and Alternaria solani at a 20 mg/L dose. Conclusion: Computational results indicated that compounds with suitable physicochemical properties, as well as those forming a hydrogen bond with His161, would have good fungicidal activity. These data could be useful for the design of bc1 complex inhibitors in the future.

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