103898-11-9

Basic information

• Product Name: TERT-BUTYL N,N-BIS(2-HYDROXYETHYL)CARBAMATE
• Synonyms: TERT-BUTYL N,N-BIS(2-HYDROXYETHYL)CARBAMATE;N-BOC-DIETHANOLAMINE;BOC-DIETHANOLAMINE;Bis(2-hydroxyethyl)amine, N-BOC protected;tert-Butyl bis(2-hydroxyethyl)carbamate;CarbaMic acid, bis(2-hydroxyethyl)-, 1,1-diMethylethyl ester;N-Boc-diethanolamine >=98.0% (GC);1-Boc-diethanolamine
• CAS NO: 103898-11-9
• Molecular Formula: C₉H₁₉NO₄
• Molecular Weight: 205.25
• Mol File: 103898-11-9.mol
• Article Data: 34

Chemical Properties

• Boiling Point: 324.2 °C at 760 mmHg
• Flash Point: 149.9 °C
• Appearance: Colorless/Liquid or Oil
• Density: 1.085 g/mL at 20 °C(lit.)
• Vapor Pressure: 1.95E-05mmHg at 25°C
• Refractive Index: n20/D 1.461
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 14.29±0.10(Predicted)
• BRN: 4386562
• CAS DataBase Reference: TERT-BUTYL N,N-BIS(2-HYDROXYETHYL)CARBAMATE(CAS DataBase Reference)
• NIST Chemistry Reference: TERT-BUTYL N,N-BIS(2-HYDROXYETHYL)CARBAMATE(103898-11-9)
• EPA Substance Registry System: TERT-BUTYL N,N-BIS(2-HYDROXYETHYL)CARBAMATE(103898-11-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• F: 10-21
• Hazardous Substances Data: 103898-11-9(Hazardous Substances Data)

Usage

Description

tert-butyl bis(2-hydroxyethyl)carbamate is a branched PEG with a tert-butyl protecting group and two hydroxyl end groups. The t-butyl group can be deprotected under acidic conditions. The hydroxyl group can react to further derivatize the compound. The hydrophilic PEG linker increases the water solubility of the compound in aqueous media.

Chemical Properties

Light yellow clear liquid

Uses

Building block for the synthesis of cationic lipids, nucleosides, etc.

InChI:InChI=1/C9H19NO4/c1-9(2,3)14-8(13)10(4-6-11)5-7-12/h11-12H,4-7H2,1-3H3

Upstream product

• 41840-28-2 S-tert-butoxycarbonyl-4,6-dimethyl-2-mercaptopyrimidine 
• 111-42-2 2,2'-iminobis[ethanol] 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 944070-20-6 4-[(1R)-1-(4-fluorophenyl)ethyl]piperazine-1-carboxylic acid tert-butyl ester 
• 1258939-38-6 tert-butyl bis(2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethyl)carbamate 
• 791-28-6 Triphenylphosphine oxide 
• 1140502-97-1 2-oxo-4-morpholinecarboxylic acidtert-butyl ester 
• 1447666-69-4 C₃₃H₃₅N₅O₈ 
• 1314808-22-4 1-((tert-butoxycarbonyl)(2-oxoethyl)amino)-6-phenylhex-3-yn-2-yl acetate 
• 1314808-21-3 1-((tert-butoxycarbonyl)(2-((tert-butyldimethylsilyl)oxy)ethyl)amino)-6-phenylhex-3-yn-2-yl acetate 
• 1314808-20-2 tert-butyl (2-((tert-butyldimethylsilyl)oxy)ethyl)(2-hydroxy-6-phenylhex-3-yn-1-yl)carbamate 
• 1314807-49-2 1-((tert-butoxycarbonyl)(2-hydroxybutyl)amino)-6-phenylhex-3-yn-2-yl acetate 
• 1314807-48-1 1-((tert-butoxycarbonyl)(2-hydroxyethyl)amino)-6-phenylhex-3-yn-2-yl acetate 
• 1314807-57-2 tert-butyl 2-(4-phenylbut-1-yn-1-yl)morpholine-4-carboxylate 
• 1300042-69-6 tert-butyl 10-(2-(3-tert-butyl-4-methoxy-5-morpholinophenyl)-2-oxoethyl)-9-imino-2,3,5,6,10,11-hexahydro-[1,4,7]dioxazonino[2,3-f]isoindole-4(9H)-carboxylate 

Relevant articles and documents

Low molecular weight PEI-based fluorinated polymers for efficient gene delivery

Fluorinated biomaterials have been reported to have promising features as non-viral gene carriers. In this study, a series of fluorinated polymeric gene carriers were synthesized via Michael addition from low molecular weight polyethyleneimine (PEI) and f

Low molecular weight PEI-based polycationic gene vectors via Michael addition polymerization with improved serum-tolerance

A series of polycationic gene delivery vectors were synthesized via Michael addition from low molecular weight PEI and linking compounds with various heteroatom compositions. Agarose gel electrophoresis results reveal that these polymers can well condense plasmid DNA and can protect DNA from degradation by nuclease. The formed polyplexes, which are stable toward serum, have uniform spherical nanoparticles with appropriate sizes around 200-350 nm and zeta-potentials about +40 mV. In vitro experiments show that these polymers have lower cytotoxicity and higher transfection efficiency than 25 KDa PEI. Furthermore, the title materials exhibit excellent serum tolerance. With the present of 10% serum, up to 19 times higher transfection efficiency than PEI was obtained, and no obvious decrease of TE was observed even the serum concentration was raised to >40%. Flow cytometry and confocal microscopy studies also demonstrate the good serum tolerance of the materials.

Thermally-activated chemiluminescent squaraine rotaxane endoperoxide with green emission

A squaraine rotaxane endoperoxide with a truncated squaraine chromophore undergoes a cycloreversion reaction and emits green light that can be transferred to red acceptor dyes. The results demonstrate that chemiluminescence emission for squaraine rotaxane endoperoxides comes from the excited squaraine inside the rotaxane.

SYNTHESE D'α-AMINODIALDEHYDES

The first N-protected aminodialdehydes have been syntesized by oxidation of N-protected aminodiols or from aminodiacids by reduction of N-Boc di (N-metoxy N-methyl) amides.

Dual polyrotaxane: One-pot synthesis of topological polymer by using metathesis reaction

The topological polyrotaxane was built from an ammonium salt as an axle component bearing one olefin and one bulky unit at the end of chain and the derivative of dibenzo-24-crown-8 (DB24C8) as a wheel component having one terminal olefin. In this system, two kinds of reactions work at the same time as a driving force of the polymer construction. One is the inclusion reaction between the ammonium salt part of axle and the wheel, another is metathesis reaction between olefins of the axle and olefins of the wheel. Copyright

Assisted enzyme replacement therapy

Reagents and methods useful for the synthesis of conjugates comprising guanidinylated cyclic acetals are provided. Also provided are methods for increasing the cellular uptake of various therapeutic compounds and treatment modalities using these conjugates.