1038990-46-3Relevant academic research and scientific papers
Identification of novel benzimidazole series of potent and selective ORL1 antagonists
Okamoto, Osamu,Kobayashi, Kensuke,Kawamoto, Hiroshi,Ito, Satoru,Satoh, Atsushi,Kato, Tetsuya,Yamamoto, Izumi,Mizutani, Sayaka,Hashimoto, Masaya,Shimizu, Atsushi,Sakoh, Hiroki,Nagatomi, Yasushi,Iwasawa, Yoshikazu,Takahashi, Hiroyuki,Ishii, Yasuyuki,Ozaki, Satoshi,Ohta, Hisashi
scheme or table, p. 3278 - 3281 (2009/04/05)
Structure-activity studies on benzimidazole lead 1 obtained from library screening led to the discovery of potent and selective ORL1 antagonist 28, 5-chloro-2-[(1-ethyl-1-methylpropyl)thio]-6-[4-(2-hydroxyethyl)piperazin-1-yl]-1H-benzimidazole, which is s
