1038995-80-0Relevant academic research and scientific papers
Design and discovery of new antiproliferative 1,2,4-triazin-3(2H)-ones as tubulin polymerization inhibitors targeting colchicine binding site
Eissa, Ibrahim H.,Dahab, Mohammed A.,Ibrahim, Mohamed K.,Alsaif, Nawaf A.,Alanazi,Eissa, Sally I.,Mehany, Ahmed B.M.,Beauchemin, André M.
, (2021/05/26)
Thirty-five new colchicine binding site inhibitors have been designed and synthesized based on the 1,2,4-triazin-3(2H)-one nucleus. Such molecules were synthesized through a cascade reaction between readily accessible α-amino ketones and phenyl carbazate
Design, synthesis, and in vitro antitumor activity of new 1,4-diarylimidazole-2-ones and their 2-thione analogues
Congiu, Cenzo,Cocco, Maria Teresa,Onnis, Valentina
, p. 989 - 993 (2008/09/20)
A series of new 1,4-diarylimidazol-2(3H)-one derivatives and their 2-thione analogues has been prepared and evaluated in vitro for antitumor activity against the NCI human cancer cell panel. Compounds bearing a 3,4,5-trimethoxyphenyl ring linked to either
