1038996-15-4Relevant articles and documents
Fluorinated piperidine acetic acids as γ-secretase modulators
Stanton, Matthew G.,Hubbs, Jed,Sloman, David,Hamblett, Christopher,Andrade, Paula,Angagaw, Minilik,Bi, Grace,Black, Regina M.,Crispino, Jamie,Cruz, Jonathan C.,Fan, Eric,Farris, Georgia,Hughes, Bethany L.,Kenific, Candia M.,Middleton, Richard E.,Nikov, George,Sajonz, Peter,Shah, Sanjiv,Shomer, Nirah,Szewczak, Alexander A.,Tanga, Flobert,Tudge, Matthew T.,Shearman, Mark,Munoz, Benito
scheme or table, p. 755 - 758 (2010/05/19)
We report herein a novel series of difluoropiperidine acetic acids as modulators of γ-secretase. Synthesis of 2-aryl-3,3-difluoropiperidine analogs was facilitated by a unique and selective β-difluorination with Selectfluor. Compounds 1f and 2c were selec