1039-83-4

Upstream product

• 100-01-6 4-nitro-aniline 
• 708-06-5 2-hydroxynaphthalene-1-carbaldehyde 

Downstream Products

• 111422-29-8 C₁₇H₁₄N₂O 
• 98003-08-8 (CH₃)3SiOAl(OC₁₀H₆CHNC₆H₄NO₂)2 
• 97982-55-3 C₆H₅AsO₃^(2-)*Al⁽³⁺⁾*NO₂C₆H₄NCHC₁₀H₆O^(1-) = C₆H₅AsO₃Al(OC₁₀H₆CHNC₆H₄NO₂) 

Relevant academic research and scientific papers

D-PET coupled ESIPT phenomenon for fluorescent turn-on detection of hydrogen sulfide

A d-PET coupled ESIPT based probe has been designed and synthesized for the selective detection of H2S, among the other ions and various sulfur species such as cysteine and glutathione, in aqueous media via the hydrogen sulfide induced reduction of nitro functionalities, and has further been utilized for the imaging of H2S in intracellular systems. The Royal Society of Chemistry.

Syntheses, characterization and catalytic activities of half-sandwich ruthenium complexes with naphthalene-based Schiff base ligands

Four ruthenium(II) p-cymene complexes with naphthalene-based Schiff base ligands [Ru(p-cymene)LCl] (2a–2d) have been synthesized and characterized. The half-sandwich ruthenium complexes were characterized by 1H and 13C NMR spectra, elemental analyses, and infrared spectrometry. The molecular structures of 2a, 2b, and 2c were confirmed by single-crystal X-ray diffraction. Furthermore, these half-sandwich ruthenium complexes are highly active catalysts for the hydrogenation of nitroarenes to anilines using NaBH4 as the reducing agent in ethanol at room temperature.

Synthesis, Spectroscopic Characterization, and XAFS Studies of Cu(II) Complexes with Bidentate Schiff Bases Derived from 2-Hydroxy-1-Naphthaldehyde

Abstract: The new complexes of compositions [CuL1] and [CuL2] were prepared by treating with [1-(((4-nitrophenyl)imino)methyl)naphthalene-2-ol] (L1) and [1-(((4-chlorophenyl)imino)methyl)naphthalene-2-ol] (L2) ligands with Cu(OAc)2·H2O, respectively. Both Schiff base ligand act as bidentate ligands. The complexes were investigated by single crystal X-ray diffraction (XRD), X-ray absorption fine structure (XAFS), Fourier transform infrared spectroscopy (FTIR), and field emission scanning electron microscopy (FE-SEM). The X-ray diffraction studies suggest a monoclinic crystal system for the complexes.

Efficacy of novel schiff base derivatives as antifungal compounds in combination with approved drugs against candida albicans

Background: The increasing incidence of fungal infections, especially caused by Candida albicans, and their increasing drug resistance has drastically increased in recent years. Therefore, not only new drugs but also alternative treatment strategies are promptly required. Methods: We previously reported on the synergistic interaction of some azole and non-azole compounds with fluconazole for combination antifungal therapy. In this study, we synthesized some non-azole Schiff-base derivatives and evaluated their antifungal activity profile alone and in combination with the most commonly used antifungal drugs-fluconazole (FLC) and amphotericin B (AmB) against four drug susceptible, three FLC resistant and three AmB resistant clinically isolated Candida albicans strains. To further analyze the mechanism of antifungal action of these compounds, we quantified total sterol contents in FLC-susceptible and resistant C. albicans isolates. Results: A pyrimidine ring-containing derivative SB5 showed the most potent antifungal activity against all the tested strains. After combining these compounds with FLC and AmB, 76% combinations were either synergistic or additive while as the rest of the combinations were indifferent. Interestingly, none of the combinations was antagonistic, either with FLC or AmB. Results interpreted from fractional inhibitory concentration index (FICI) and isobolograms revealed 4-10-fold reduction in MIC values for synergistic combinations. These compounds also inhibit ergosterol biosynthesis in a concentration-dependent manner, supported by the results from docking studies. Conclusion: The results of the studies conducted advocate the potential of these compounds as new antifungal drugs. However, further studies are required to understand the other mechanisms and in vivo efficacy and toxicity of these compounds.

Synthesis of a series of new platinum organometallic complexes derived from bidentate Schiff-base ligands and their catalytic activity in the hydrosilylation and dehydrosilylation of styrene

The synthesis and properties of a novel class of platinum complexes containing Schiff bases as O,N-bidentate ligands is described as are the solution and solid state properties of the uncomplexed ligands. The platinum complexes were prepared from [PtBr2(COD)] (COD = 1,5-cyclooctadiene) and N-(2-hydroxy-1-naphthalidene)aniline derivatives in the presence of base (NaOBut). Instead of a substitution reaction to afford cationic species, the addition of the Schiff base ligands results in both the formal loss of two equivalents of bromide and addition of hydroxide to the COD ligand of the complexes. It is proposed that this reaction proceeds through a cationic platinum complex [Pt(N-O)(COD)]Br which then undergoes addition of water and loss of HBr. An example of a dinuclear platinum complex in which two cyclo-octene ligands are bridged by an ether linkage is also reported. The platinum complexes were evaluated as catalysts for the hydrogenative and dehydrogenative silylation of styrene, the resulting behaviour is substituent, time and temperature dependent.

Synthesis, spectroscopic characterization, catalytic and antibacterial studies of ruthenium(III) Schiff base complexes

The bidentate Schiff base ligands (HLn) have been synthesized by condensation of 2-hydroxy-l-naphthaldehyde with aniline and its p-substituted derivatives in ethanol. Ruthenium(III) complexes of the type [Ru(Ln)2(H2O)2]Cl have been synthesized by the reaction of RuCl3·nH2O with the Schiff base ligands (in a molar ratio 1:2) in ethanol. The ligands and their Ru(III) complexes have been characterized by elemental analysis, magnetic susceptibility, spectroscopic (FTIR, UV-vis, 1H NMR and X-ray diffraction) and thermal analysis techniques. All the ruthenium(III) complexes are found to be stable, paramagnetic, low spin and octahedrally coordinated by the ligands through the nitrogen atom of the azomethine (-CN-) group and the oxygen atom of the deprotonated phenolic group. The molecular and electronic structures of the investigated ligands (HLn) were also studied using quantum chemical calculations. The complexes (1, 3 and 5) exhibited a catalytic activity for the oxidation of benzoin to benzil with moderate to high yield in the presence of sodium periodate as co-oxidant. The antibacterial activities of the ligands (HLn) and their Ru(III) complexes towards Gram positive and Gram negative bacteria have been investigated.

Synthesis and Characterisation of Binuclear Silicon-Aluminium and Arsenic-Aluminium Complexes with Schiff Bases

Trimethylsilyl acetate or phenylarsonic acid on reaction with aluminium isopropoxide yields two new series of complexes of the types, (CH3)3Si-O-Al(OPri)2 and .The isopropoxy groups in these derivatives further undergo facile reactions with bidentate Schiff bases giving coloured complexes of the types (CH3)3Si-O-Al(SB-H)2 and respectively, where SB-H is deprotonated form of the Schiff base.The Si-Al type of compounds are monomeric in nature and nonelectrolytes in DMF and DMSO, where the As-Al type of derivatives are insoluble in most of the organic solvents and appear to be polymeric in nature.A few compounds have been found to be quite effective as potential pesticides.