1039022-12-2

Basic information

• Product Name: 3-(4-amino-piperidin-1-yl)-5-chloro-benzamide
• CAS NO: 1039022-12-2
• Molecular Weight: 253.732
• Mol File: 1039022-12-2.mol

Chemical Properties

• CAS DataBase Reference: 3-(4-amino-piperidin-1-yl)-5-chloro-benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-amino-piperidin-1-yl)-5-chloro-benzamide(1039022-12-2)
• EPA Substance Registry System: 3-(4-amino-piperidin-1-yl)-5-chloro-benzamide(1039022-12-2)

Safety Data

• Hazardous Substances Data: 1039022-12-2(Hazardous Substances Data)

Usage

Chemical compound

3-(4-amino-piperidin-1-yl)-5-chloro-benzamide

Structure

Consists of a benzene ring with a chlorine substitution and an amide group linked to a piperidine ring with an amino group at the 4-position

Pharmacological properties

Studied for its potential as an anti-tumor agent and for its ability to inhibit the growth of cancer cells

Potential applications

Medicinal chemistry and drug development

Biological activity

Potential as a receptor modulator or enzyme inhibitor

Further research

Needed to fully understand potential uses and effects

Upstream product

• 1303510-86-2 C₁₇H₂₄ClN₃O₃ 

Downstream Products

• 1033952-79-2 3-chloro-5-{4-[4-(4-cyano-2,6-dimethyl-phenoxy)-pyrimidin-2-ylamino]-piperidin-1-yl}-benzamide 

Relevant articles and documents

Exploration of piperidine-4-yl-aminopyrimidines as HIV-1 reverse transcriptase inhibitors. N-Phenyl derivatives with broad potency against resistant mutant viruses

Further investigation of the recently reported piperidine-4-yl- aminopyrimidine class of non-nucleoside reverse transcriptase inhibitors (NNRTIs) has been carried out. Thus, preparation of a series of N-phenyl piperidine analogs resulted in the identification of 3-carboxamides as a particularly active series. Analogs such as 28 and 40 are very potent versus wild-type HIV-1 and a broad range of NNRTI-resistant mutant viruses. Synthesis, structure-activity relationship (SAR), clearance data, and crystallographic evidence for the binding motif are discussed.

Non-nucleoside reverse transcriptase inhibitors

The present invention provides for compounds useful for treating an HIV infection, or preventing an HIV infection, or treating AIDS or ARC. The compounds of the invention are of formula I wherein R1, R2, R3, R4, R5a, R5b, R6a, R6b and X are as herein defined. Also disclosed in the present invention are methods of treating an HIV infection with compounds defined herein and pharmaceutical compositions containing said compounds.