1039022-14-4

Basic information

• Product Name: 2-(4-amino-piperidin-1-yl)-benzamide
• CAS NO: 1039022-14-4
• Molecular Weight: 219.286
• Mol File: 1039022-14-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-(4-amino-piperidin-1-yl)-benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-amino-piperidin-1-yl)-benzamide(1039022-14-4)
• EPA Substance Registry System: 2-(4-amino-piperidin-1-yl)-benzamide(1039022-14-4)

Safety Data

• Hazardous Substances Data: 1039022-14-4(Hazardous Substances Data)

Usage

Physical form

White solid

Molecular weight

254.3 g/mol

Use in research

Potential antagonist of GPR55 receptor

Involvement in physiological processes

Pain sensation, bone density regulation, and cancer cell proliferation

Potential therapeutic applications

Treatment of inflammatory and neuropathic pain, modulation of endocannabinoid system

Status of research

Ongoing investigation into mechanism of action and pharmacological properties.

Upstream product

• 1303510-82-8 C₁₇H₂₅N₃O₃ 

Downstream Products

• 1033952-81-6 2-{4-[5-bromo-4-(4-cyano-2,6-dimethyl-phenoxy)-pyrimidin-2-ylamino]-piperidin-1-yl}-benzamide 

Relevant articles and documents

Exploration of piperidine-4-yl-aminopyrimidines as HIV-1 reverse transcriptase inhibitors. N-Phenyl derivatives with broad potency against resistant mutant viruses

Further investigation of the recently reported piperidine-4-yl- aminopyrimidine class of non-nucleoside reverse transcriptase inhibitors (NNRTIs) has been carried out. Thus, preparation of a series of N-phenyl piperidine analogs resulted in the identification of 3-carboxamides as a particularly active series. Analogs such as 28 and 40 are very potent versus wild-type HIV-1 and a broad range of NNRTI-resistant mutant viruses. Synthesis, structure-activity relationship (SAR), clearance data, and crystallographic evidence for the binding motif are discussed.