103905-49-3

Basic information

• Product Name: 4-(DIMETHYLAMINOMETHYL)-6-FLUORO-2-METHOXYPHENOL
• Synonyms: 4-(DIMETHYLAMINOMETHYL)-6-FLUORO-2-METHOXYPHENOL;4-((DiMethylaMino)Methyl)-2-fluoro-6-Methoxyphenol
• CAS NO: 103905-49-3
• Molecular Formula: C₁₀H₁₄FNO₂
• Molecular Weight: 199.22
• Mol File: 103905-49-3.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-(DIMETHYLAMINOMETHYL)-6-FLUORO-2-METHOXYPHENOL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(DIMETHYLAMINOMETHYL)-6-FLUORO-2-METHOXYPHENOL(103905-49-3)
• EPA Substance Registry System: 4-(DIMETHYLAMINOMETHYL)-6-FLUORO-2-METHOXYPHENOL(103905-49-3)

Safety Data

• Hazardous Substances Data: 103905-49-3(Hazardous Substances Data)

Upstream product

• 50-00-0 formaldehyd 
• 73943-41-6 2-fluoro-6-methoxyphenol 
• 74-89-5 methylamine 
• 124-40-3 dimethyl amine 

Downstream Products

• 79418-78-3 3-fluoro-4-hydroxy-5-methoxybenzaldehyde 
• 127685-76-1 1-fluoro-2-hydroxy-3-methoxy-5-methylbenzene 
• 99424-78-9 3,4-dimethoxy-5-fluorophenethylamine 
• 71924-61-3 3-fluoro-4,5-dimethoxybenzaldehyde 
• 1470110-70-3 4-(tert-butyldimethylsilanyloxy)-3-fluoro-5-methoxyphenol 
• 1470110-64-5 formic acid 4-(tert-butyldimethylsilanyloxy)-3-fluoro-5-methoxyphenyl ester 
• 1470111-29-5 C₃₆H₃₇FO₁₀ 
• 1470111-21-7 C₄₂H₅₁FO₁₀Si 
• 1089186-95-7 1-(3-fluoro-4-hydroxy-5-methoxyphenyl)-N,N,N-trimethylmethanaminium iodide 
• 104716-83-8 6,7-Bis-benzyloxy-8-fluoro-1-(3,4,5-trimethoxy-benzyl)-1,2,3,4-tetrahydro-isoquinoline 
• 104716-81-6 2-(3,4-Bis-benzyloxy-5-fluoro-phenyl)-ethylamine 
• 104716-76-9 3,4-dihydroxy-5-fluorobenzyl cyanide 
• 104716-80-5 N-[2-(3,4-Bis-benzyloxy-5-fluoro-phenyl)-ethyl]-2-(3,4,5-trimethoxy-phenyl)-acetamide 
• 104716-77-0 3,4-bis(benzyloxy)-5-fluorobenzyl cyanide 

Relevant articles and documents

New Synthesis of 2-Fluoroisovanilin and 5-Fluorovanilin

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cGAS ANTAGONIST COMPOUNDS

Disclosed are novel compounds of Formula (I) that are cGAS antagonists, methods of preparation of the compounds, pharmaceutical compositions comprising the compounds, and their use in medical therapy.

The carbonate analogues of 5′-halogenated resiniferatoxin as TRPV1 ligands

A series of carbonate analogues of 5′-halogenated RTX have been investigated in order to examine the effect of the carbonate group as a linker and the role of halogens in the reversal of activity from agonism to antagonism for rat and human TRPV1 heterologously expressed in Chinese hamster ovary cells. The carbonate analogues showed similar activities to the corresponding RTX derivatives in rat TRPV1 but lower potency in human TRPV1. 5-Halogenation converted the agonists to partial agonists or full antagonists and the extent of antagonism reflected the order of I > Br > Cl > F, with a somewhat greater extent of antagonism for the derivatives of the 4-amino RTX surrogates compared to the corresponding derivatives of RTX itself. The carbonate analogues of I-RTX (60) and 5-bromo-4-amino-RTX (66) were potent and full antagonists with Ki(ant) = 2.23 and 2.46 nM, respectively, for rat TRPV1, which were ca. 5-fold more potent than I-RTX (2) under our conditions. The conformational analysis of the I-RTX-carbonate (60) indicated that its bent conformation was similar to that of I-RTX, consistent with compound 60 and I-RTX showing comparable potent antagonism.