103909-86-0

Basic information

• Product Name: 3-AMINO CROTONIC ACID CINNAMYL ESTER
• Synonyms: 3-AMINO CROTONIC ACID CINNAMYL ESTER;CINNAMYL 3-AMINOCROTONATE;(E)-Cinnamyl 3-aminobut-2-enoate;3- amino -2- acid ester of maleic acid
• CAS NO: 103909-86-0
• Molecular Formula: C13H15NO2
• Molecular Weight: 217.26
• EINECS: 1592732-453-0
• Mol File: 103909-86-0.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 386.3±30.0 °C(Predicted)
• Appearance: /
• Density: 1.102±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 5.26±0.70(Predicted)
• Stability: Light Sensitive
• CAS DataBase Reference: 3-AMINO CROTONIC ACID CINNAMYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 3-AMINO CROTONIC ACID CINNAMYL ESTER(103909-86-0)
• EPA Substance Registry System: 3-AMINO CROTONIC ACID CINNAMYL ESTER(103909-86-0)

Safety Data

• Hazardous Substances Data: 103909-86-0(Hazardous Substances Data)

Usage

General Description

3-AMINO CROTONIC ACID CINNAMYL ESTER is a chemical compound with the molecular formula C13H15NO2. It is an ester formed from cinnamyl alcohol and 3-amino crotonic acid, and it is commonly used in the synthesis of pharmaceuticals and organic compounds. This chemical has a pale yellow color and a characteristic odor. It is known for its use in the production of fragrances, flavors, and as a reagent in chemical reactions. It is also used in the manufacturing of various cosmetic and personal care products. Additionally, it has potential applications in the field of medicinal chemistry and drug design.

Upstream product

• 57582-46-4 cinnamyl 3-oxobutanoate 
• 61363-91-5 (E)-(3-phenylallyl) 3-oxo-butyrate 
• 4407-36-7 (2E)-3-phenyl-2-propen-1-ol 

Downstream Products

• 132203-70-4 cilnidipine 

Relevant articles and documents

Preparation method of cilnidipine

The invention relates to a preparation method of cilnidipine. The invention provides a preparation method of cinnamyl 3-aminobut-2-enoate, which comprises the following step: carrying out amination reaction on cinnamyl acetoacetate and ammonium carbonate to obtain the cinnamyl 3-aminobut-2-enoate. On the basis, the invention further provides a method for preparing cilnidipine by taking the cinnamyl 3-aminobut-2-enoate as a raw material. The method provided by the invention is relatively low in reaction temperature, relatively short in reaction time, relatively high in product yield and purity,and simple in aftertreatment.

Preparation method of cilnidipine impurity or cilnidipine oxide impurity

The invention relates to a preparation process of a compound and particularly relates to a preparation method of a cilnidipine impurity or a cilnidipine oxide impurity. The preparation method of the cilnidipine impurity which is cinnamyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-diformate at least comprises a step (1) of taking cinnamyl acetyl acetate, cinnamyl 3-amino-aminocrotonateand m-nitrobenzaldehyde as raw materials, heating and reacting to obtain cinnamyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-diformate. The preparation method of the cilnidipine oxide impurity which is cinnamyl 2,6-dimethyl-4-(2-nitrophenyl)-pyridine-3,5-diformate also comprises a step (2) of oxidizing cinnamyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-diformate to obtaincinnamyl 2,6-dimethyl-4-(2-nitrophenyl)-pyridine-3,5-diformate. The preparation method is easily available in raw materials, simple and convenient to operate and easy to control; the prepared productis high in purity and is suitably used as working reference substance.

1,4-dihydropyridine derivatives

1,4-dihydropyridine derivatives of formula (I): STR1 wherein Ar1 and Ar2 each represent an unsubstituted or substituted aromatic hydrocarbon or aromatic heterocyclic group; and R1 represents --CO2 R2, --SO2 R3, --COR4, --CON(R5)2, --CH--or --NO2 in which R2 is hydrogen, a straight chain, branched chain or cyclic saturated hydrocarbon group, which may have a substituent or a straight chain, branched chain or cyclic unsaturated hydrocarbon group having 2 to 10 carbon atoms, which may have a substituent, R3 is an alkyl group having 1 to 4 carbon atoms, R4 is an alkyl group having 1 to 4 carbon atoms or a phenyl group; and R5 is an alkyl group having 1 to 4 carbon atoms.