10391-47-6

Basic information

• Product Name: 19-Norkaur-16-en-18-oicacid, 2,15-dihydroxy-, (2b,4a,15a)-
• Synonyms: 19-Norkaur-16-en-18-oicacid, 2b,15a-dihydroxy- (8CI); Atractyligenin (7CI);1H-2,10a-Ethanophenanthrene, 19-norkaur-16-en-18-oic acid deriv.; (4a)-2b,15a-Dihydroxy-19-norkaur-16-en-18-oic acid
• CAS NO: 10391-47-6
• Molecular Formula: C19H28 O4
• Molecular Weight: 320.429
• Mol File: 10391-47-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 515.2°Cat760mmHg
• Flash Point: 279.5°C
• Density: 1.25g/cm³
• CAS DataBase Reference: 19-Norkaur-16-en-18-oicacid, 2,15-dihydroxy-, (2b,4a,15a)-(CAS DataBase Reference)
• NIST Chemistry Reference: 19-Norkaur-16-en-18-oicacid, 2,15-dihydroxy-, (2b,4a,15a)-(10391-47-6)
• EPA Substance Registry System: 19-Norkaur-16-en-18-oicacid, 2,15-dihydroxy-, (2b,4a,15a)-(10391-47-6)

Safety Data

• Hazardous Substances Data: 10391-47-6(Hazardous Substances Data)

Usage

General Description

The chemical "19-Norkaur-16-en-18-oicacid, 2,15-dihydroxy-, (2b,4a,15a)-" is a naturally occurring compound belonging to the class of diterpenoids. It is characterized by its structure containing a 19-norsteroid backbone with a hydroxyl group at position 2 and 15. The stereochemistry at these positions is denoted as (2b,4a,15a). This chemical has been found to possess various biological activities, including anti-inflammatory and antioxidant properties. It is also of interest for its potential therapeutic applications in conditions such as cancer and cardiovascular disease. Further research is needed to fully understand the pharmacological potential and mechanisms of action of this compound.

Upstream product

• 17754-44-8 (-)-atractyloside potassium salt 
• 1398-13-6 atractyloside 

Downstream Products

• 5691-65-6 Hydroatractylitriol 
• 926026-11-1 C₃₆H₃₉NO₆ 
• 926026-17-7 C₂₇H₃₆O₅SN₂ 

Relevant articles and documents

Structural characterization and antimicrobial evaluation of atractyloside, atractyligenin, and 15-didehydroatractyligenin methyl ester

We report the first complete structure elucidation of the ent-kaurane diterpenoid glycoside atractyloside (1) by means of NMR and X-ray diffractometry techniques. Extensive one- and two-dimensional NMR experiments were employed to assign the proton and carbon signals of 1, and crystallography experiments established the configurations of all stereogenic centers. Furthermore, we present a novel semisynthetic route for the preparation of the highly cytotoxic aglycone derivative of 1, 15-didehydroatractyligenin methyl ester (3). All compounds were tested for their antibiotic activity against Enterococcus faecalis, Escherichia coli, and several strains of Staphylococcus aureus, including fluoroquinoloneresistant (SA1199B) and two epidemic MRSA (EMRSA-15 and -16) strains. Compound 3 exhibited moderate activity against all of the Staph. aureus strains with an MIC value of 128 mg/L.