103914-61-0

Basic information

• Product Name: 6-CHLORO-2-(4-METHYLPHENYL)QUINOLINE-4-CARBOXYLICACID
• Synonyms: 6-CHLORO-2-(4-METHYLPHENYL)QUINOLINE-4-CARBOXYLICACID;6-chloro-2-(4-methylphenyl)quinoline-4-carboxylic acid(SALTDATA: FREE);6-chloro-2-(4-methylphenyl)-4-quinolinecarboxylic acid;6-chloro-2-(4-methylphenyl)cinchoninic acid;Oprea1_280104;STK327023
• CAS NO: 103914-61-0
• Molecular Formula: C₁₇H₁₂ClNO₂
• Molecular Weight: 297.74
• Mol File: 103914-61-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 490.7°C at 760 mmHg
• Flash Point: 250.6°C
• Appearance: /
• Density: 1.336g/cm³
• Vapor Pressure: 1.91E-10mmHg at 25°C
• Refractive Index: 1.672
• CAS DataBase Reference: 6-CHLORO-2-(4-METHYLPHENYL)QUINOLINE-4-CARBOXYLICACID(CAS DataBase Reference)
• NIST Chemistry Reference: 6-CHLORO-2-(4-METHYLPHENYL)QUINOLINE-4-CARBOXYLICACID(103914-61-0)
• EPA Substance Registry System: 6-CHLORO-2-(4-METHYLPHENYL)QUINOLINE-4-CARBOXYLICACID(103914-61-0)

Safety Data

• Hazardous Substances Data: 103914-61-0(Hazardous Substances Data)

Usage

General Description

6-CHLORO-2-(4-METHYLPHENYL)QUINOLINE-4-CARBOXYLIC ACID is a chemical compound with the molecular formula C18H12ClNO2. It is a quinoline derivative with a chlorine atom and a carboxylic acid functional group attached to the quinoline ring. 6-CHLORO-2-(4-METHYLPHENYL)QUINOLINE-4-CARBOXYLICACID is often used in the pharmaceutical industry for the synthesis of potential drug candidates due to its diverse pharmacological properties. It may have applications in the treatment of various diseases and conditions, but further research is needed to fully understand its potential uses. Additionally, it may be used as a building block in organic synthesis for the production of other compounds with specific properties and functions. Overall, 6-CHLORO-2-(4-METHYLPHENYL)QUINOLINE-4-CARBOXYLIC ACID is a versatile chemical with potential applications in drug development and organic synthesis.

InChI:InChI=1/C17H12ClNO2/c1-10-2-4-11(5-3-10)16-9-14(17(20)21)13-8-12(18)6-7-15(13)19-16/h2-9H,1H3,(H,20,21)

Upstream product

• 104-87-0 4-methyl-benzaldehyde 
• 106-47-8 4-chloro-aniline 
• 127-17-3 2-oxo-propionic acid 
• 17630-76-1 5-chloroindole 2,3-dione 
• 122-00-9 para-methylacetophenone 

Downstream Products

• 103914-62-1 6-chloro-2-(4-methylphenyl)-4-quinolinecarbonyl chloride 
• 462628-15-5 (6-chloro-2-p-tolyl-quinolin-4-yl)-methanol 

Relevant articles and documents

Discovery of a Quinoline-4-carboxamide Derivative with a Novel Mechanism of Action, Multistage Antimalarial Activity, and Potent in Vivo Efficacy

The antiplasmodial activity, DMPK properties, and efficacy of a series of quinoline-4-carboxamides are described. This series was identified from a phenotypic screen against the blood stage of Plasmodium falciparum (3D7) and displayed moderate potency but with suboptimal physicochemical properties and poor microsomal stability. The screening hit (1, EC50 = 120 nM) was optimized to lead molecules with low nanomolar in vitro potency. Improvement of the pharmacokinetic profile led to several compounds showing excellent oral efficacy in the P. berghei malaria mouse model with ED90 values below 1 mg/kg when dosed orally for 4 days. The favorable potency, selectivity, DMPK properties, and efficacy coupled with a novel mechanism of action, inhibition of translation elongation factor 2 (PfEF2), led to progression of 2 (DDD107498) to preclinical development.

Approaches to a photocleavable protecting group for alcohols

A new protecting group for the alcohol functionality was devised and shown to be removed photochemically under ultraviolet light in the presence of a radical scavenger in high yields.