103927-75-9

Upstream product

• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 1021149-41-6 C₁₆H₂₁NO₂ 
• 106-38-7 para-bromotoluene 
• 576-22-7 2-Bromo-m-xylene 
• 4786-20-3 but-2-enenitrile 
• 696-62-8 para-iodoanisole 

Relevant academic research and scientific papers

Palladium(II) Acetate Catalyzed Reductive Heck Reaction of Enones; A Practical Approach

A surprisingly practical Pd(OAc)2 or Pd(TFA)2-catalyzed reductive Heck reaction between aryl iodides and α,β-unsaturated ketones is described using N,N-diisopropylethylamine (DIPEA, Hünigs base) as the reductant. In general, 1 mol % of Pd(OAc)2 is sufficient to afford good yields using electron-rich or halogen-substituted aryl iodides. Electron-deficient aryl iodides preferentially give homocoupling. Enones containing aryl or bulky substituents on the β-carbon react smoothly, producing mainly reductive Heck product, whereas enones with alkyl substituents on the β-carbon afford a mixture of reductive Heck and Heck product. Deuterium labeling experiments show that the reaction is a bona fide reductive Heck reaction and exclude a Heck reaction-conjugate reduction cascade. Deeply DIPEA about... A palladium-catalyzed reductive Heck reaction of aryl iodides to α,β-unsaturated ketones is described using N,N diisopropylethylamine (DIPEA, Hünigs base) as the reductant. A deuterium labeling study shows that the reaction is a bona fide reductive Heck reaction and excludes a Heck reaction-conjugate reduction cascade.

Pd-arylurea complexes for the Heck arylation of crotonic and cinnamic substrates

A catalyst consisting of the 1:2 complex of Pd(OAc)2 (1 mol %) with N-(4-carbethoxy)-phenylurea promotes the Heck arylation of a range of crotonic and cinnamic substrates, including aldehydes, ketones, esters, and nitriles, with electron-rich - but not electron-deficient - aryl iodides.

Synthetic application of intramolecular cyanoboration on the basis of removal and conversion of a tethering group by palladium-catalyzed retro-allylation

A new synthetic strategy, involving utilization of a tethered intramolecular reaction with a removable tether, was demonstrated by the intramolecular cyanoboration-retro-allylation sequence. Georg Thieme Verlag Stuttgart.

BICYCLIC BENZENOID AMINOALKYLENE ETHERS AND THIOETHERS, PHARMACEUTICAL COMPOSITIONS AND USE

A class of bicyclic benzenoid aminoalkylene ether and thioether compounds exhibiting pharmacological activity, including anti-secretory and anti-ulcerogenic activity, pharmaceutical compositions comprising these compounds, and methods for the treatment of gastrointestinal hyperacidity and ulcerogenic disorders in mammals using said compositions.