103935-48-4

Basic information

• Product Name: 3-bromopropyl-1-trifluoromethanesulfonate
• Synonyms: 3-bromopropyl-1-trifluoromethanesulfonate
• CAS NO: 103935-48-4
• Molecular Formula: C₄H₆BrF₃O₃S
• Molecular Weight: 271.05
• Mol File: 103935-48-4.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 220.3°Cat760mmHg
• Flash Point: 87.1°C
• Appearance: /
• Density: 1.788g/cm³
• Vapor Pressure: 0.168mmHg at 25°C
• Refractive Index: 1.43
• CAS DataBase Reference: 3-bromopropyl-1-trifluoromethanesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: 3-bromopropyl-1-trifluoromethanesulfonate(103935-48-4)
• EPA Substance Registry System: 3-bromopropyl-1-trifluoromethanesulfonate(103935-48-4)

Safety Data

• Hazardous Substances Data: 103935-48-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C4H6BrF3O3S/c5-2-1-3-11-12(9,10)4(6,7)8/h1-3H2

Upstream product

• 627-18-9 1-bromo-3-propanol 
• 358-23-6 trifluoromethylsulfonic anhydride 
• 2923-28-6 silver trifluoromethanesulfonate 
• 109-64-8 1,3-dibromo-propane 

Downstream Products

• 1443007-97-3 (S)-N-((1S,2S)-2-hydroxy-1,2-diphenylethyl)-N,2-dimethylpyrrolidine-2-carboxamide 
• 527758-37-8 [4-(3-Bromo-propoxy)-cyclohexyl]-benzene 
• 108607-98-3 1-bromo-3-[¹⁸F]fluoropropane 
• 106114-45-8 8-<4-(4-fluorophenyl)-4-oxobutyl>-1-phenyl-4-(3-fluoropropoxy)-1,3,8-triazaspiro<4.5>dec-3-ene 
• 106114-44-7 3-N-(3-fluoropropyl)spiperone 
• 352-91-0 1-Bromo-3-fluoropropane 
• 106114-51-6 1-(3-fluoropropyl)-4-phenylpiperazine 

Relevant articles and documents

Synthesis and evaluation of new 18F-labelled acetamidobenzoxazolone-based radioligands for imaging of the translocator protein (18 kDa, TSPO) in the brain

The visualization of the activated microglia/TSPO is one of the main aspects of neuroimaging. Here we describe two new 18F-labelled molecules, 2-[5-(4-[18F]fluoroethoxyphenyl)- ([18F]2) and 2-[5-(4-[18F]fluoropr

Synthetic method for cyclopropyl diphenyl sulfonium trifluoromethanesulfonic salt

The invention provides a synthetic method for cyclopropyl diphenyl sulfonium trifluoromethanesulfonic salt. The synthetic method includes the steps that (a) 3-halogen-1-propyl alcohol and trifluoromethanesulfonic anhydride serve as raw materials for synth

Synthesis and evaluation of novel radioligands for positron emission tomography imaging of metabotropic glutamate receptor subtype 1 (mGluR1) in rodent brain

We designed three novel positron emission tomography ligands, N-(4-(6-(isopropylamino)pyrimidin-4-yl)-1,3-thiazol-2-yl)-4-[ 11C]methoxy-N-methylbenzamide ([11C]6), 4-[ 18F]fluoroethoxy-N-[4-[6-(isopropylamino)pyrimidin-4-yl]-1, 3-thiazol-2-yl]-N-methylbenzamide ([18F]7), and 4-[ 18F]fluoropropoxy-N-[4-[6-(isopropylamino)pyrimidin-4-yl]-1, 3-thiazol-2-yl]-N-methylbenzamide ([18F]8), for imaging metabotropic glutamate receptor type 1 (mGluR1) in rodent brain. Unlabeled compound 6 was synthesized by benzoylation of 4-pyrimidinyl-2-methylaminothiazole 10, followed by reaction with isopropylamine. Removal of the methyl group in 6 gave phenol precursor 12 for radiosynthesis. Two fluoroalkoxy analogues 7 and 8 were prepared by reacting 12 with tosylates 13 and 14. Radioligands [ 11C]6, [18F]7, and [18F]8 were synthesized by O-[11C]methylation or [18F]fluoroalkylation of 12. Compound 6 showed high in vitro binding affinity for mGluR1, whereas 7 and 8 had weak affinity. Autoradiography using rat brain sections showed that [ 11C]6 binding is aligned with the reported distribution of mGluR1 with high specific binding in the cerebellum and thalamus. PET study with [ 11C]6 in rats showed high brain uptake and a similar distribution pattern to that in autoradiography, indicating the usefulness of [ 11C]6 for imaging brain mGluR1.