1039361-81-3

Basic information

• Product Name: (R)-1-Boc-3-(2-Oxoethyl)Piperidine
• Synonyms: (R)-1-Boc-3-(2-Oxoethyl)Piperidine;1-Piperidinecarboxylic acid, 3-(2-oxoethyl)-, 1,1-diMethylethyl ester, (3R)-;(R)-tert-butyl 3-(2-oxoethyl)piperidine-1-carboxylate
• CAS NO: 1039361-81-3
• Molecular Formula: C12H21NO3
• Molecular Weight: 227.30004
• Mol File: 1039361-81-3.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (R)-1-Boc-3-(2-Oxoethyl)Piperidine(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-1-Boc-3-(2-Oxoethyl)Piperidine(1039361-81-3)
• EPA Substance Registry System: (R)-1-Boc-3-(2-Oxoethyl)Piperidine(1039361-81-3)

Safety Data

• Hazardous Substances Data: 1039361-81-3(Hazardous Substances Data)

Usage

General Description

(R)-1-Boc-3-(2-Oxoethyl)Piperidine is a chemical compound with a molecular formula of C13H24N2O3. It is commonly used as an intermediate in the synthesis of various pharmaceutical compounds. (R)-1-Boc-3-(2-Oxoethyl)Piperidine is a piperidine derivative with a 1-Boc (tert-butyloxycarbonyl) protecting group at the nitrogen atom and a 2-oxoethyl functional group on the piperidine ring. It is a colorless oil that is soluble in organic solvents such as dichloromethane and ethanol. (R)-1-Boc-3-(2-Oxoethyl)Piperidine is commonly utilized in the pharmaceutical industry for the synthesis of various drugs and potential drug candidates.

Upstream product

• 389889-62-7 t-butyl (3R)-3-(2-hydroxyethyl)tetrahydropyridine-1(2H)-carboxylate 
• 1039361-80-2 C₁₂H₂₀N₂O₂ 

Relevant articles and documents

Discovery of N-Alkyl Piperazine Side Chain Based CXCR4 Antagonists with Improved Drug-like Properties

A novel series of CXCR4 antagonists with piperidinyl and piperazinyl alkylamine side chains designed as butyl amine replacements are described. Several of these compounds showed similar activity to the parent compound TIQ-15 (5) in a SDF-1 induced calcium flux assay. Preliminary structure-activity relationship investigations led us to identify a series containing N-propyl piperazine side chain analogs exemplified by 16 with improved off-target effects as measured in a muscarinic acetylcholine receptor (mAChR) calcium flux assay and in a limited drug safety panel screen. Further efforts to explore SAR and optimize drug properties led to the identification of the N′-ethyl-N-propyl-piperazine tetrahydroisoquinoline derivative 44 and the N-propyl-piperazine benzimidazole compound 37, which gave the best overall profiles with no mAChR or CYP450 inhibition, good permeability in PAMPA assays, and metabolic stability in human liver microsomes.