103949-59-3

Basic information

• Product Name: 3,4-Dichloro-2-(hydroxymethyl)pyridine
• Synonyms: 3,4-Dichloro-2-(hydroxymethyl)pyridine
• CAS NO: 103949-59-3
• Molecular Formula: C6H5Cl2NO
• Molecular Weight: 178.016
• Mol File: 103949-59-3.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3,4-Dichloro-2-(hydroxymethyl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-Dichloro-2-(hydroxymethyl)pyridine(103949-59-3)
• EPA Substance Registry System: 3,4-Dichloro-2-(hydroxymethyl)pyridine(103949-59-3)

Safety Data

• Hazardous Substances Data: 103949-59-3(Hazardous Substances Data)

Usage

General Description

3,4-Dichloro-2-(hydroxymethyl)pyridine is a chemical compound with the molecular formula C6H5Cl2NO. It is a highly reactive and water-soluble compound that is primarily used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. 3,4-Dichloro-2-(hydroxymethyl)pyridine has various applications in the production of pesticides, herbicides, and fungicides. It is also used as a building block for the synthesis of other organic compounds, such as chiral ligands and catalysts. Additionally, 3,4-Dichloro-2-(hydroxymethyl)pyridine is utilized as a reagent in organic synthesis and has shown potential as an antibacterial and antifungal agent. However, it is important to handle and store this compound with caution, as it can be harmful if ingested or inhaled, and may cause skin and eye irritation.

Upstream product

• 497-19-8 sodium carbonate 
• 103949-58-2 3,4-dichloro-2-methyl-pyridine 
• 1211517-04-2 3,4-dichloropicolinaldehyde 
• 97944-40-6 4-amino-3-chloro-2-methylpyridine 
• 18437-58-6 3-methyl-4-pyridinamine 
• 108004-98-4 3,4-dichloro-2-methylpyridine N-oxide 

Relevant articles and documents

Electrophilicity and nucleophilicity of commonly used aldehydes

The present approach for determining the electrophilicity (E) and nucleophilicity (N) of aldehydes includes a kinetic study of KMNO4 oxidation and NaBH4 reduction of aldehydes. A transition state analysis of the KMNO4 promoted aldehyde oxidation reaction has been performed, which shows a very good correlation with experimental results. The validity of the experimental method has been tested using the experimental activation parameters of the two reactions. The utility of the present approach is further demonstrated by the theoretical versus experimental relationship, which provides easy access to E and N values for various aldehydes and offers an at-a-glance assessment of the chemical reactivity of aldehydes in various reactions. the Partner Organisations 2014.

2-[[(4-Amino-2-pyridyl)methyl]sulfinyl]benzimidazole H+/K+-ATPase inhibitors. The relationship between pyridine basicity, stability, and activity

The benzimidazole sulfoxide class of antisecretory H+/K+-ATPase inhibitors need to possess high stability under neutral physiological conditions yet rearrange rapidly at low pH to the active sulfenamide 2. Since the initial reaction involves internal nucleophilic attack by the pyridine nitrogen, control of the pyridine pK(a) is critical. In this paper we show that by utilizing the powerful electron-donating effect of a 4-amino substituent on the pyridine, moderated by the electron-withdrawing effect of a 3- or 5-halogen substituent, a combination of high potency (as inhibitors of histamine-stimulated gastric acid secretion) and good stability under physiological conditions can be obtained. Furthermore, the role of the steric interaction between the 3/5-substituents and the 4-substituent in modifying the electron-donating ability of the 4-amino group is exemplified, and additional factors affecting stability are identified. One compound, in particular, 2-[[(3-chloro-4-morpholino-2-pyridyl)methyl]sulfinyl]-5-methoxy-(1H)- benzimidazole (3a, SK and F 95601), was chosen for further development and evaluation in man.