103971-44-4

Basic information

• Product Name: (5-broMo-4-chloropyridin-2-yl)Methanol
• Synonyms: (5-broMo-4-chloropyridin-2-yl)Methanol;5-bromo-4-chloro-2-Pyridinemethanol
• CAS NO: 103971-44-4
• Molecular Formula: C6H5BrClNO
• Molecular Weight: 222.467
• Mol File: 103971-44-4.mol

Chemical Properties

• Boiling Point: 296.7±35.0 °C(Predicted)
• Appearance: /
• Density: 1.785±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 12.73±0.10(Predicted)
• CAS DataBase Reference: (5-broMo-4-chloropyridin-2-yl)Methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (5-broMo-4-chloropyridin-2-yl)Methanol(103971-44-4)
• EPA Substance Registry System: (5-broMo-4-chloropyridin-2-yl)Methanol(103971-44-4)

Safety Data

• Hazardous Substances Data: 103971-44-4(Hazardous Substances Data)

Usage

Uses

As of the current understanding, there are no specific applications reported for (5-bromo-4-chloropyridin-2-yl)methanol. However, its chemical structure may hold potential in various fields, such as:
Used in Chemical Research:
(5-bromo-4-chloropyridin-2-yl)methanol may be used as a research compound for studying its chemical properties and reactivity, given its unique combination of a pyridine ring and a methanol group.
Used in Pharmaceutical Research:
Due to the presence of a pyridine ring, which is a common structural motif in many bioactive molecules, (5-bromo-4-chloropyridin-2-yl)methanol could be employed as a starting material or intermediate in the synthesis of potential pharmaceutical agents.

Upstream product

• 62516-08-9 5-bromo-2-methyl-4-nitropyridine 1-oxide 
• 31181-64-3 5-bromo-2-methyl-pyridine-N-oxide 
• 3430-13-5 5-bromo-2-methylpyridine 
• 103971-43-3 3-bromo-4-chloro-6-methylpyridine N-oxide 

Downstream Products

• 103971-48-8 4-pyrrolidino-5-bromo-2-hydroxymethylpyridine 
• 1060802-25-6 5-bromo-4-chloropicolinic acid 

Relevant articles and documents

INHIBITORS OF AKT ACTIVITY

Invented are novel pyrazole compounds, the use of such compounds as inhibitors of protein kinase B activity and in the treatment of cancer and arthritis.

2-[[(4-Amino-2-pyridyl)methyl]sulfinyl]benzimidazole H+/K+-ATPase inhibitors. The relationship between pyridine basicity, stability, and activity

The benzimidazole sulfoxide class of antisecretory H+/K+-ATPase inhibitors need to possess high stability under neutral physiological conditions yet rearrange rapidly at low pH to the active sulfenamide 2. Since the initial reaction involves internal nucleophilic attack by the pyridine nitrogen, control of the pyridine pK(a) is critical. In this paper we show that by utilizing the powerful electron-donating effect of a 4-amino substituent on the pyridine, moderated by the electron-withdrawing effect of a 3- or 5-halogen substituent, a combination of high potency (as inhibitors of histamine-stimulated gastric acid secretion) and good stability under physiological conditions can be obtained. Furthermore, the role of the steric interaction between the 3/5-substituents and the 4-substituent in modifying the electron-donating ability of the 4-amino group is exemplified, and additional factors affecting stability are identified. One compound, in particular, 2-[[(3-chloro-4-morpholino-2-pyridyl)methyl]sulfinyl]-5-methoxy-(1H)- benzimidazole (3a, SK and F 95601), was chosen for further development and evaluation in man.

Benzimidazoles

Compounds of structure (I) and pharmaceutically acceptable salts thereof, in which R5 and R6 are the same or different and are each hydrogen, C1-6alkyl or C3-6cycloalkyl or together with the nitrogen atom to which they are attached form an acetidino, pyrrolidino, piperidino, piperazino, N-C1-4alkylpiperazino or morpholino group and one of R7 and R8 is halogen, and the other is hydrogen, halogen or C1-6alkyl; processes for their preparation, intermediates useful in their preparation, pharmaceutical compositions containing them and their use as inhibitors of gastric acid secretion.