103971-44-4

Basic information

• Product Name: (5-broMo-4-chloropyridin-2-yl)Methanol
• Synonyms: (5-broMo-4-chloropyridin-2-yl)Methanol;5-bromo-4-chloro-2-Pyridinemethanol
• CAS NO: 103971-44-4
• Molecular Formula: C6H5BrClNO
• Molecular Weight: 222.467
• Mol File: 103971-44-4.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 296.7±35.0 °C(Predicted)
• Appearance: /
• Density: 1.785±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 12.73±0.10(Predicted)
• CAS DataBase Reference: (5-broMo-4-chloropyridin-2-yl)Methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (5-broMo-4-chloropyridin-2-yl)Methanol(103971-44-4)
• EPA Substance Registry System: (5-broMo-4-chloropyridin-2-yl)Methanol(103971-44-4)

Safety Data

• Hazardous Substances Data: 103971-44-4(Hazardous Substances Data)

Usage

General Description

"(5-bromo-4-chloropyridin-2-yl)methanol" is a chemical compound with the molecular formula C6H5BrClNO. (5-bromo-4-chloropyridin-2-yl)methanol belongs to the class of organic compounds known as pyridinylmethanols. Pyridinylmethanols are compounds containing a pyridine ring, which is a heterocyclic aromatic ring system, conjugated to a methanol molecule. In terms of physical properties, it exhibits a molecular weight of 238.47 g/mol. As of the current understanding, there are no specific uses reported for this compound. However, given its structure, it may hold potential in various chemical and pharmacological research activities. However, no specific health or environmental hazards have been specified for this compound, implying that data on its toxicity or handling precautions may not yet be well-established.

Upstream product

• 31181-64-3 5-bromo-2-methyl-pyridine-N-oxide 
• 62516-08-9 5-bromo-2-methyl-4-nitropyridine 1-oxide 
• 3430-13-5 5-bromo-2-methylpyridine 
• 103971-43-3 3-bromo-4-chloro-6-methylpyridine N-oxide 

Downstream Products

• 1060802-25-6 5-bromo-4-chloropicolinic acid 
• 103971-48-8 4-pyrrolidino-5-bromo-2-hydroxymethylpyridine 

Relevant articles and documents

INHIBITORS OF AKT ACTIVITY

Invented are novel pyrazole compounds, the use of such compounds as inhibitors of protein kinase B activity and in the treatment of cancer and arthritis.

2-[[(4-Amino-2-pyridyl)methyl]sulfinyl]benzimidazole H+/K+-ATPase inhibitors. The relationship between pyridine basicity, stability, and activity

The benzimidazole sulfoxide class of antisecretory H+/K+-ATPase inhibitors need to possess high stability under neutral physiological conditions yet rearrange rapidly at low pH to the active sulfenamide 2. Since the initial reaction involves internal nucleophilic attack by the pyridine nitrogen, control of the pyridine pK(a) is critical. In this paper we show that by utilizing the powerful electron-donating effect of a 4-amino substituent on the pyridine, moderated by the electron-withdrawing effect of a 3- or 5-halogen substituent, a combination of high potency (as inhibitors of histamine-stimulated gastric acid secretion) and good stability under physiological conditions can be obtained. Furthermore, the role of the steric interaction between the 3/5-substituents and the 4-substituent in modifying the electron-donating ability of the 4-amino group is exemplified, and additional factors affecting stability are identified. One compound, in particular, 2-[[(3-chloro-4-morpholino-2-pyridyl)methyl]sulfinyl]-5-methoxy-(1H)- benzimidazole (3a, SK and F 95601), was chosen for further development and evaluation in man.