1039736-29-2

Upstream product

• 1039736-84-9 C₁₉H₂₂ClN₃O₃ 
• 2131-55-7 4-Chlorophenyl isothiocyanate 
• 220298-96-4 4‐(tert‐butoxycarbonylamino)benzylamine 

Downstream Products

• 1039733-95-3 1N-(4-chlorophenyl)-N'-[4-({[2-(dimethylamino)-7-methylquinazolin-4-yl]amino}methyl)phenyl]urea 
• 1039733-96-4 N-(4-chlorophenyl)-N'-[4-({[2-(dimethylamino)-6-methylquinazolin-4-yl]amino}methyl)phenyl]urea 
• 1039736-31-6 N-(4-chlorophenyl)-N'-[4-({[2-(chloro)-6-methylquinazolin-4-yl]amino}methyl)phenyl]urea 
• 1039736-30-5 N-(4-chlorophenyl)-N'-[4-({[2-(chloro)-7-methylquinazolin-4-yl]amino}methyl)phenyl]urea 

Relevant academic research and scientific papers

Synthesis and evaluation of fluoroquinolone derivatives as substrate-based inhibitors of bacterial efflux pumps

Bacterial efflux pump systems contribute to antimicrobial resistance in pathogenic bacteria. The co-administration of bacterial efflux pump inhibitors with antibiotics is being pursued to overcome efflux-mediated resistance to antibiotics. In this study we investigated a strategy for converting broad-spectrum efflux pump substrates, fluoroquinolone antibacterial agents which are inherently recognized by most efflux transporters, into expanded spectrum efflux pump inhibitors. Employing this strategy against organisms expressing efflux pumps from the MFS, MATE and RND classes of pump systems, we report here the identification of an ofloxacin-based EPI that is a potent inhibitor of MFS (NorA) and MATE (MepA) efflux pumps in Staphylococcus aureus. The methods described here outline a process that we feel will be broadly applicable to the systematic identification of bacterial efflux pump inhibitors.

AMINO-SUBSTITUTED QUINAZOLINE DERIVATIVES AS INHIBITORS OF β-CANTENIN/TCF-4 PATHWAY AND CANCER TREATMENT AGENTS

The present invention relates to amino-substituted quinazoline derivatives as inhibitors of β-catenin/tcf-4 pathway, which can be useful in the treatment of cancer; to processes for their preparation; to pharmaceutical compositions comprising them; and to methods of using them.