1039739-38-2Relevant academic research and scientific papers
A tissue-selective nonsteroidal progesterone receptor modulator: 7,9-difluoro-5-(3-methylcyclohex-2-enyl)-2,2,4-trimethyl-1,2-dihydrochromeno[3, 4-f]quinoline
Pedram, Bijan,Van Oeveren, Arjan,Mais, Dale E.,Marschke, Keith B.,Verbost, Pieter M.,Groen, Marinus B.,Zhi, Lin
supporting information; experimental part, p. 3696 - 3699 (2009/05/11)
The progesterone receptor plays an important role in the female reproductive system. Here we describe the discovery of a new selective progesterone receptor modulator (SPRM). In rats, the lead compound, 7,9-difluoro-5-(3-methylcyclohex-2-enyl)-2,2,4-trimethyl-1,2-dihydrochromeno[3, 4-f]quinoline (5c), inhibited ovulation and showed full efficacy in uterine and vaginal tissue but was a mixed partial agonist/antagonist in breast tissue. The compound also suppressed ovulation in monkeys, but in contrast to currently approved steroidal PR agonists, it did not suppress estradiol levels.
