1039749-45-5Relevant articles and documents
New and expeditious tandem sequence Aza-Michael/intramolecular nucleophilic substitution route to substituted γ-lactams: Synthesis of the tricyclic core of (±)-martinellines
Comesse, Sebastien,Sanselme, Morgane,Daich, Adam
, p. 5566 - 5569 (2008)
(Chemical Equation Presented) A new and highly diastereoselective tandem reaction azaMichael/intramolecular nucleophilic substitution is presented. This unprecedented tandem reaction between N-substituted α-bromoacetamides and Michael acceptors proceeds with good yields and excellent diastereoselectivity to provide the corresponding trisubstituted γ-lactam systems. An application to the concise synthesis of the tricyclic core of (±)-martinelline alkaloids is also described.