1039757-81-7

Basic information

• Product Name: 1-[(4R)-4-phenyl-2-thioxo-3-thiazolidinyl]-1-Propanone
• Synonyms: 1-[(4R)-4-phenyl-2-thioxo-3-thiazolidinyl]-1-Propanone;1-[(4R)-4-Phenyl-2-thioxo-3-thiazolidinyl]-1-propanone,99%e.e.
• CAS NO: 1039757-81-7
• Molecular Formula: C₁₂H₁₃NOS₂
• Molecular Weight: 251.36772
• Mol File: 1039757-81-7.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-[(4R)-4-phenyl-2-thioxo-3-thiazolidinyl]-1-Propanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[(4R)-4-phenyl-2-thioxo-3-thiazolidinyl]-1-Propanone(1039757-81-7)
• EPA Substance Registry System: 1-[(4R)-4-phenyl-2-thioxo-3-thiazolidinyl]-1-Propanone(1039757-81-7)

Safety Data

• Hazardous Substances Data: 1039757-81-7(Hazardous Substances Data)

Usage

Chemical structure

Contains a thiazolidine ring

Usage

Drug for the treatment of type 2 diabetes

Mechanism of action

Increases the body's sensitivity to insulin

Additional effects

Anti-inflammatory and anti-atherosclerotic properties

Potential benefits

Treatment of cardiovascular disease

Side effects

Weight gain, increased risk of heart failure

Contraindications

Not recommended for individuals with liver disease

Upstream product

• 79-03-8 propionyl chloride 
• 185137-29-5 (4S)-4-phenyl-1,3-thiazolidine-2-thione 
• 123-62-6 propionic acid anhydride 
• 110199-18-3 (4R)-4-phenyl-1,3-thiazolidine-2-thione 
• 20989-17-7 (2S)-2-phenylglycinol 
• 802294-64-0 propionic acid 

Downstream Products

• 1039757-85-1 (S)-N-[(2R,3S)-3-methoxy-2-methyl-3-phenylpropanoyl]-4-phenyl-1,3-thiazolidine-2-thione 

Relevant articles and documents

A acylation of the synthesis method of sulfur on behalf of the oxazolidone

The invention discloses a method for acylation of the synthesis method of sulfur on behalf of the oxazolidone. Synthesis method of the invention, comprising the following steps: in the non-protic organic solvent, the compound III and under the action of a

Synthesis and Fungicidal Activity of Simple Structural 1,3-Thiazolidine-2-Thione Derivatives

A series of simple structural 1,3-thiazolidine-2-thione derivatives with various substituents on the S-, N-, 4-, and 5-positions was synthesized with high yields from various vicinal amino alcohols via two steps and screened for their antifungal activity. Bioassay results reveal that some thiazolidine-2-thione derivatives show strong antifungal activities against P. capsici, G. zeae, S. sclerotiorum, A. alternata, B. cinerea, or R. solani. The SAR analysis indicates that N-acyl substituted and 4-alkyl substituents can enhance the antifungal activity. Notably, 4-isopropyl-N-propionylthiazoldine-2-thione shows excellent activity against B. cinerea and G. zeae with IC50 values at 3.7 g/mL and 6.5 g/mL, respectively, and 4-isobutyl-N-propionylthiazoldine-2-thione shows remarkable fungicidal activity against R. solani, S. sclerotiorum, and G. zeae with IC50 values at 1.0 g/mL, 12.1 g/mL, and 11.0 g/mL, respectively. GRAPHICAL ABSTRACT.

Absolute configuration of lactams and oxazolidinones using kinetic resolution catalysts

A simple method for determining the absolute configuration of oxazolidinones, lactams, and their derivatives using kinetic resolution catalysts is described. The optically pure substrates were acylated using the (S)-HBTM and the (R)-HBTM catalyst, and the faster reaction was determined. An empirical mnemonic was developed for the assignment of the absolute configuration based on the fast-reacting catalyst.

On the influence of chiral auxiliaries in the stereoselective cross-coupling reactions of titanium enolates and acetals

Titanium enolates from chiral N-propanoyl-1,3-thiazolidine-2-thiones containing bulky substituents at C4 turned out to be excellent platforms to get highly stereocontrolled cross-coupling reactions with acetals. Related oxazolidinethiones also afforded go