1039834-46-2Relevant academic research and scientific papers
Copper-Catalyzed Double C-N Bond Formation for the Synthesis of Diverse Benzimidazoles from N -Alkyl-2-iodoaniline and Sodium Azide
Chen, Zhengkai,Li, Hongli,Cao, Gangjian,Xu, Jianfeng,Miao, Maozhong,Ren, Hongjun
supporting information, p. 504 - 508 (2017/02/24)
An efficient approach to the synthesis of benzimidazole derivatives has been achieved by copper-catalyzed double C-N bonds formation of N-alkyl-2-iodoaniline and sodium azide. The reaction was supposed to proceed through copper-catalyzed tandem reaction of SNAr reaction, aerobic oxidation of C(sp3)-H bond and intramolecular C-N bond formation sequence. Structurally diverse 2-aryl, alkenyl and alkyl benzoimidazole derivatives were assembled by this methodology.
Potassium tert-butoxide promoted intramolecular arylation via a radical pathway
Roman, Daniela Sustac,Takahashi, Yoko,Charette, Andre B.
, p. 3242 - 3245 (2011/08/02)
Potassium tert-butoxide mediated intramolecular cyclization of aryl ethers, amines, and amides was efficiently performed under microwave irradiation to provide the corresponding products in high regioisomeric ratios. The reaction proceeds via single-electron transfer to initiate the formation of an aryl radical, followed by a kinetically favored 5-exo-trig and subsequent ring expansion.
