1039914-85-6

Basic information

• Product Name: 5-chloro-N-(4-nitrophenyl)pentanamide
• Synonyms: 5-chloro-N-(4-nitrophenyl)pentanamide;PentanaMide, 5-chloro-N-(4-nitrophenyl)-
• CAS NO: 1039914-85-6
• Molecular Formula: C₁₁H₁₃ClN₂O₃
• Molecular Weight: 257
• Mol File: 1039914-85-6.mol
• Article Data: 8

Chemical Properties

• Melting Point: 121-123℃
• Boiling Point: 476.3±30.0 °C(Predicted)
• Appearance: /
• Density: 1.314
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 13.70±0.70(Predicted)
• CAS DataBase Reference: 5-chloro-N-(4-nitrophenyl)pentanamide(CAS DataBase Reference)
• NIST Chemistry Reference: 5-chloro-N-(4-nitrophenyl)pentanamide(1039914-85-6)
• EPA Substance Registry System: 5-chloro-N-(4-nitrophenyl)pentanamide(1039914-85-6)

Safety Data

• Hazardous Substances Data: 1039914-85-6(Hazardous Substances Data)

Usage

Uses

5-Chloro-N-(4-nitrophenyl)-pentanamide is used in process for the preparation of Apixaban and intermediates thereof.

Upstream product

• 1575-61-7 5-Chlorovaleroyl chloride 
• 100-01-6 4-nitro-aniline 

Downstream Products

• 1191091-32-3 N-(4-nitrophenyl)-5-(pyrrolidin-1-yl)pentanamide 
• 536759-91-8 4,5,6,7-tetrahydro-1-(4-methoxyphenyl)-6-(4-nitrophenyl)-7-oxo- 1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester 
• 1421823-20-2 ethyl 6-(4-(N-(4-chlorobutyl)carboxamido)phenyl)-1-(4-methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate 

Relevant articles and documents

Alternate synthesis of apixaban (BMS-562247), an inhibitor of blood coagulation factor Xa

An alternate approach to apixaban was described. The synthesis features a novel and cost-effective synthetic strategy to construct a key N-phenylvalerolactam intermediate 4 from 4-nitroaniline. In addition, the modified synthetic route avoids the use of expensive reagents and significantly improves reaction yields. As demonstrated practically, apixaban was successfully synthesized in overall good yield (35%). Copyright Taylor & Francis Group, LLC.

PROCESS FOR THE PREPARATION OF APIXABAN AND INTERMEDIATES THEREOF

The present invention refers to novel process for the preparation of Apixaban. Further, the invention also related to a process for the preparation of intermediate of Apixaban from very basic and cheap row material i.e. Aniline which is widely commercially available. The present invention provides process for preparation of Apixaban using a different sequence of synthetic steps and does not involve use of Ullmann reaction.

A pyridine derivative

The present invention relates to the field of pharmaceutical chemistry, specifically to a class of compounds containing lactam and derivative thereof, and especially to a pyridine derivative as shown in general formula (I), preparation method and the use thereof as a Factor Xa inhibitor. The present invention further relates to the medical use of the compound and derivative thereof in preparation of anticoagulant drugs, particularly to the use in preparation of drugs for preventing or treating thrombosis or embolism.