103994-89-4

Basic information

• Product Name: 2-BROMO-4,5-DIFLUOROBENZOYL CHLORIDE
• Synonyms: 2-BROMO-4,5-DIFLUOROBENZOYL CHLORIDE
• CAS NO: 103994-89-4
• Molecular Formula: C₇H₂BrClF₂O
• Molecular Weight: 255.44
• Mol File: 103994-89-4.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 121-123 °C(Press: 32 Torr)
• Appearance: /
• Density: 1.818±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 2-BROMO-4,5-DIFLUOROBENZOYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-4,5-DIFLUOROBENZOYL CHLORIDE(103994-89-4)
• EPA Substance Registry System: 2-BROMO-4,5-DIFLUOROBENZOYL CHLORIDE(103994-89-4)

Safety Data

• Hazard Codes: C
• Hazardous Substances Data: 103994-89-4(Hazardous Substances Data)

Upstream product

• 64695-84-7 2-bromo-4,5-difluorobenzoic acid 

Downstream Products

• 1447018-04-3 N-(2-((3-(benzylthio)-2-(methylcarbamoyl)phenyl)carbamoyl)-3-bromophenyl)-2-bromo-4,5-difluorobenzamide 
• 1432371-62-4 2-bromo-N-cyclopropyl-4,5-difluoro-N-methylbenzamide 
• 1379820-78-6 2-bromo-4,5-difluoro-N-phenylbenzamide 

Relevant articles and documents

Synthesis of Methoxy-, Methylenedioxy-, Hydroxy-, and Halo-Substituted Benzophenanthridinone Derivatives as DNA Topoisomerase IB (TOP1) and Tyrosyl-DNA Phosphodiesterase 1 (TDP1) Inhibitors and Their Biological Activity for Drug-Resistant Cancer

As a recently discovered DNA repair enzyme, tyrosyl-DNA phosphodiesterase 1 (TDP1) removes topoisomerase IB (TOP1)-mediated DNA protein cross-links. Inhibiting TDP1 can potentiate the cytotoxicity of TOP1 inhibitors and overcome cancer cell resistance to

Ni-Catalyzed Alkene Carboacylation via Amide C-N Bond Activation

We report Ni-catalyzed formal carboacylation of o-allylbenzamides with arylboronic acid pinacol esters. The reaction is triggered by oxidative addition of an activated amide C-N bond to a Ni(0) catalyst and proceeds via alkene insertion into a Ni(II)-acyl bond. The exo-selective carboacylation reaction generates 2-benzyl-2,3-dihydro-1H-inden-1-ones in moderate to high yields (46-99%) from a variety of arylboronic acid pinacol esters and substituted o-allylbenzamides. These results show that amides are practical substrates for alkene carboacylation via amide C-N bond activation, and this approach bypasses challenges associated with alkene carboacylation triggered by C-C bond activation.

Palladium-catalyzed ring-opening of cyclopropyl benzamides: Synthesis of benzo[c]azepine-1-ones via C(sp3)-H functionalization

A variety of difficult to obtain benzo[c]azepine-1-ones are synthesized via a novel palladium-catalyzed, silver-promoted intramolecular cyclization of cyclopropyl benzamides. This biologically important class of molecules is prepared in an efficient and high-yielding manner from easily accessible starting materials. Both aryl bromides and iodides are effective substrates for the transformation. Mechanistic studies indicate that the reaction proceeds through a cyclopropyl C(sp3)-H cleavage step, followed by ring-opening, deprotonation, and reductive elimination.