103995-05-7

Upstream product

• 104599-99-7 1-phenyl-6,7,8-trifluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid 
• 110-85-0 piperazine 
• 103994-87-2 7-fluoro-1-p-fluorophenyl-6,8-difluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid 
• 105859-09-4 ethyl 1-(4-fluorophenyl)-6,7,8-trifluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylate 
• 105859-07-2 ethyl 3-(4-fluoroanilino)-2-(2,3,4,5-tetrafluorobenzoyl)acrylate 

Relevant academic research and scientific papers

Quinoline antibacterial compounds

Quinoline compounds having the formula: STR1 wherein R is a phenyl or substituted phenyl group or an aromatic heterocyclic group, R1 is a hydrogen or a carboxy-protecting group and Z is an amine group or an aliphatic heterocyclic group. The com

Synthesis and Structure-Activity Relationship of 1-Aryl-6,8-difluoroquinolone Antibacterial Agents

A series of new arylfluoroquinolones has been prepared.These derivatives are characterized by having fluorine atoms at the 6- and 8-positions, substituted amino groups at the 7-position, and substituted phenyl groups at the 1-position.The in vitro antibacterial potency is greatest when the 1-substituent is 2,4-difluorophenyl and the 7-substituent is a 3-amino-1-pyrrolidinyl group. 1-(4-Fluorophenyl)-6,8-difluoro-7-piperazin-1-yl-1,4-dihydro-4-oxoquinoline-3-carboxylic acid (22) was found to possesss excellent in vitro potency and in vivo efficacy.