1040206-39-0Relevant articles and documents
Synthesis and pharmacological evaluation of peptide-mimetic protease-activated receptor-1 antagonists containing novel heterocyclic scaffolds
Severino, Beatrice,Fiorino, Ferdinando,Perissutti, Elisa,Frecentese, Francesco,Cirino, Giuseppe,Roviezzo, Fiorentina,Santagada, Vincenzo,Caliendo, Giuseppe
, p. 6009 - 6020 (2008/12/21)
Protease-activated receptor-1 (PAR-1) is a G-coupled receptor activated by α-thrombin and other proteases. In this paper we describe the synthesis and the pharmacological evaluation of novel peptide-mimetic antagonists (compounds 1-16) characterized by th