104023-01-0Relevant academic research and scientific papers
Chiral-Anion-Mediated Asymmetric Heck-Matsuda Reaction of Acyclic Alkenyl Alcohols
Zhang, Tao,Li, Wen-Ao,Shen, Hong-Cheng,Chen, Shu-Sen,Han, Zhi-Yong
, p. 1473 - 1477 (2021)
Acyclic internal alkenes are a class of challenging substrates in asymmetric Heck-type reactions due to difficulties related to both reactivity and selectivity control. Employing acyclic alkenyl alcohols, an asymmetric Heck-Matsuda reaction is developed through the strategy of chiral anion phase transfer. Various chiral ketones could be obtained in high levels of enantioselectivity. A catalytic amount of dimethyl sulfoxide (DMSO) as an additive is crucial for the reaction to suppress the palladium-hydride-mediated side reactions.
ALKYLATION DE L'ACETYLACETATE DE METHYLE PAR LE α(p-NITROPHENYL)-ETHANOL CHIRAL PAR DESHYDRATATION INTERMOLECULAIRE
Cabaret, D.,Maigrot, N.,Welvart, Z.
, p. 547 - 550 (1984)
Mitsunobu's method of acetoacetic ester alkylation by p-nitrophenyl-ethanol avoid the SRN1 reaction and is well appropriate for the correlation of absolut configuration end ee of the O and C alkylation products.
