1040232-90-3Relevant academic research and scientific papers
Highly Enantioselective Kinetic Resolution of Michael Adducts through N-Heterocyclic Carbene Catalysis: An Efficient Asymmetric Route to Cyclohexenes
Chen, Xiang-Yu,Li, Sun,Liu, Qiang,Kumar, Mukesh,Peuronen, Anssi,Rissanen, Kari,Enders, Dieter
supporting information, p. 9735 - 9738 (2018/07/25)
A highly efficient strategy for the kinetic resolution of Michael adducts was realized using a chiral N-heterocyclic carbene catalyst. The kinetic resolution provides a new convenient route to single diastereomers of cyclohexenes and Michael adducts in good yields with high enantiomeric excesses (up to 99 % ee with a selectivity factor of up to 458). This “two flies with one swat” concept allows the synthesis of these two synthetically valuable compound classes at the same time by a single transformation.
Organocatalytic asymmetric direct Michael addition of aromatic ketones to alkylidenemalononitriles
Yue, Lei,Du, Wei,Liu, Yan-Kai,Chen, Ying-Chun
, p. 3881 - 3884 (2008/09/21)
The asymmetric direct Michael addition of aromatic ketones to highly active alkylidenemalononitriles was investigated by employing a chiral primary amine 9-amino-9-deoxyepicinchonine. In general modest to good enantioselectivities (71-84% ee) could be obtained in acceptable isolated yields (48-85%) for an array of substrates.
