1040256-05-0Relevant academic research and scientific papers
Synthesis of 1(2H)-isoquinolones by the nickel-catalyzed denitrogenative alkyne insertion of 1,2,3-benzotriazin-4(3H)-ones
Miura, Tomoya,Yamauchi, Motoshi,Murakami, Masahiro
supporting information; experimental part, p. 3085 - 3088 (2009/04/12)
(Chemical Equation Presented) 1,2,3-Benzotriazin-4(3H)-ones reacted with internal and terminal alkynes in the presence of a nickel(0)/phosphine catalyst to give a wide range of substituted 1(2H)-isoquinolones in high yield. The reaction proceeded through denitrogenative activation of the triazinone moiety and the following insertion of alkynes.
